Sperm antibodies in the cervical mucus and sera and postcoital tests in infertile women

Wong, Wilbert

doi:10.1016/0028-2243(78)90050-3

Cited by 9 publications

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Secretion of immunoglobulins is lowered by presence or administration of estrogen [5]. This immunological competence of the cervix has been invoked to explain various forms of infertility [6]. This interpretation has been disputed on the basis of evidence of lack of complement system components [7,8].…”

Section: Normal Cervical Functionmentioning

confidence: 99%

Contraception and the cervix

Ansari

Gould²

1986

Adv Contracept

View full text Add to dashboard Cite

In the human and subhuman primates the uterine cervix plays an important role in the reproductive process by its permissive and inhibitory action on sperm migration from the vaginal pool into the cervical canal, the uterine cavity and the fallopian tube, the site of gamete unification and fertilization. This is accomplished through physico-chemical (amount, clarity, viscosity, pH, electrolyte composition, etc.) alteration of the cervical mucus in response to the circulating sex steroids. In an ovulatory cycle, shortly prior to and at the time of ovulation the cervical mucus becomes most receptive to the spermatozoa whereas at other times, specifically following ovulation, it becomes hostile to the spermatozoa and virtually impenetrable. This unique property of the cervical mucus may, in addition to the presently available techniques (diaphragm, cervical cap and intracervical devices), allow identification of such potential contraceptive modalities as: pH modifier - changing the pH of the cervical mucus from alkaline to acid around the time of ovulation; Electrolyte modifier - changing electrolyte composition of the cervical mucus to produce a mesh impenetrable to spermatozoa. Finally, development of a temporary localized tissue-fixed immune antibody to spermatozoa in the cervical mucus is within the realm of reality and deserves the necessary attention.

show abstract

Section: Normal Cervical Functionmentioning

confidence: 99%

Contraception and the cervix

Ansari

Gould²

1986

Adv Contracept

View full text Add to dashboard Cite

show abstract

Biochemical changes in cervical mucus‐factor infertility

et al. 1985

View full text Add to dashboard Cite

Cervical‐factor infertility has generally been attributed to the presence of antispermatozoal antibodies in the secretions of the uterine cervix, despite the fact that the incidence of sperm‐specific antibodies in these women is generally low. We report here a modification in the structure of the cervical mucus of patients with a diagnosed cervical factor. Cervical mucus from patients with a cervical factor of nonimmunological origin, collected during the periovulatory phase of the menstrual cycle, had (1) a significant decrease in the content of glycosidically bound sialic acid and (2) an increased ability to act as an acceptor for sialic acid from cytidine‐5′‐monophospho‐N‐acetylneuraminic acid (CMP‐sialic acid) when incubated with an exogenous sialyltransferase; in comparison to mucus from normal fertile women. Both siaiyltransferase and fucosyltransferase activities were detected in cervical mucus, but there was no difference between fertile normal and cervical‐factor patients using the assays described. These results reinforce a possible role for sialic acid residues and their associated glycosyltransferases in the regulation of spermatozoal–cervical mucus interaction.

show abstract

Pathologic Factors Involved in Infertility

Fox¹,

Buckley²

1982

Pathology of the Female Genital Tract

View full text Add to dashboard Cite

Sperm antibodies in the cervical mucus and sera and postcoital tests in infertile women

Cited by 9 publications

References 11 publications

Contraception and the cervix

Contraception and the cervix

Biochemical changes in cervical mucus‐factor infertility

Pathologic Factors Involved in Infertility

Contact Info

Product

Resources

About