Sperm aneuploidy after testicular cancer treatment: data from a prospective multicenter study performed within the French Centre d’Étude et de Conservation des Oeufs et du Sperme network

Abstract

Genetic counseling of TC patients should include information on the potential elevated risk of aneuploid conceptus from sperm recovered after treatment and the necessity to postpone conception up to ≥12 months after radiotherapy and ≥24 months after more than two BEP chemotherapy cycles. However, few men receiving one or two BEP cycles and some dropouts are the main limitations of this study.

The Impact of Testicular Cancer on Fertility - Literature Review

“…Radiotherapy represents the method of choice in testicular seminoma, ensuring a tumor control rate of 95% 10 .…”

“…Testicular irradiation with approximate 200 rad causes complete sterility and it is applied in case of in situ carcinoma as the unique treatment method. In this case, sperm cryopreservation should be considered before applying radiotherapy 10 .…”

“…If radiotherapy is used as an adjuvant method, the radiation dose is 60 rad. Doses greater than 100-200 rad can produce oligospermia that is reversible 10 .…”

“…Another multicenter study conducted in France by River and colab., entitled "Spermatic aneuploidy after testicular cancer treatment" underlines the importance of genetic counseling regarding the high risk of sperm aneuploidy after radiotherapy and chemotherapy 10 . Aneuploidy is a major cause of the development of some fetal genetic syndromes, such as Down syndrome 12 .…”

“…Most multicentre studies recommend sperm cryopreservation before applying any treatment in testicular cancer. It represents an effi cient method in case of unpleasant side eff ects on fertility after surgery or radiotherapy and chemotherapy 10 . Surely this method increases the patient's psychological comfort and stabilizes the couple's relationship.…”