Sperm and oocyte donor selection and management: experience of a 10 year follow-up of more than 2100 candidates

Garrido, Nicolás; Zuzuarregui, J.L.; Meseguer, M.; Simón, Carlos; Remohı́, José; Pellicer, A.

doi:10.1093/humrep/17.12.3142

Cited by 84 publications

(48 citation statements)

References 5 publications

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“…The complete list of serological determinations, as well as the frequency of finding positive results on the serologies has been analyzed in detail by our group, demonstrating that this frequency in our sperm donor population is not greater than that present in infertile couples or in the general population (2).…”

Section: Methodsmentioning

confidence: 72%

Parameters Affecting the Results in a Program of Artificial Insemination With Donor Sperm. A 12-year Retrospective Review of More Than 1800 Cycles

Zuzuarregui

Meseguer

Garrido

et al. 2004

J Assist Reprod Genet

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Purpose : We aimed to establish the influence of the parameters affecting artificial insemination (AI) results in order to describe the ideal situations to achieve the best results as well as to adequately counsel the patients undergoing these treatments about their pregnancy chances. Methods : We performed a controlled retrospective clinical study over more than one decade in a total of 1858 cycles in 710 patients. Clinical histories and computer registers were systematically reviewed between January 1990 and June 2002. We analyzed the influence of diverse factors affecting AI results such as patient's age, ovarian stimulation, and seminal characteristics to offer a detailed description of the technique. Results : Less than 35-years-old, smooth ovarian stimulation and 5 million of progressive motile sperm inseminated two consecutive days are the optimum conditions for achieving good results. Also, period of time that sperm remained frozen do not affect the result. Furthermore, we present the likely or expected outcomes of these treatments depending on the male and female etiologies. Conclusions : We discourage AI in aged patients, and strongly recommend undergoing ovarian stimulation. Nonetheless, we must reach an adequate amount of sperm with good motility in order to inseminate with maximum guaranties of success.

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Section: Methodsmentioning

confidence: 72%

Parameters Affecting the Results in a Program of Artificial Insemination With Donor Sperm. A 12-year Retrospective Review of More Than 1800 Cycles

Zuzuarregui

Meseguer

Garrido

et al. 2004

J Assist Reprod Genet

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“…Semen samples for the infertile group were obtained from males attending our centre for assisted conception (n = 91) and fertile sperm samples were selected from semen donors who get pregnancies within the donor artificial insemination program (n = 60) (13). Inclusion criteria to consider a male infertile were duration of infertility of at least 12 months, nonsevere seminal pathology (more than 15 mill./mL, 25% sperm with progressive motility, and total number of motile sperm higher than 40 million), and no other demonstrable cause of infertility in the female partner.…”

Section: Methodsmentioning

confidence: 99%

Relationship Between Standard Semen Parameters, Calcium, Cholesterol Contents, and Mitochondrial Activity in Ejaculated Spermatozoa From Fertile and Infertile Males

Meseguer

Garrido

Martínez-Conejero

et al. 2004

J Assist Reprod Genet

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Purpose : To correlate levels of cholesterol (CH), calcium (Ca 2+ ), and mitochondrial activity (MA) with the standard semen parameters and to compare them between fertile and infertile men. Methods : We studied 151 semen samples from infertile (n = 60) or fertile (n = 91) males. Basic sperm parameters were analyzed. Ca 2+ and CH concentrations on seminal plasma were determined by enzymoimmunoanalysis. Intracellular Ca 2+ and CH concentrations in the sperm plasma membrane and mitochondrial activity by fluorometry. Results : There was a significant positive correlation between sperm membrane CH and sperm morphology. Intracellular Ca 2+ was lower in infertile patients compared to fertile. No differences were found regarding Ca 2+ and CH concentrations in seminal plasma. MA is directly and strongly related with sperm motility. Conclusions : Intracellular concentrations of Ca 2+ and the proportion of CH in the sperm membrane are two important markers of the sperm quality due to its direct relationship with sperm morphology and fertility potential.

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“…All donors undergo testing for human immunodeficiency virus, cytomegalovirus, and hepatitis B and C and karyotype screening (42). Women with important health problems or personal or familial history of hereditary diseases are not recruited as donors.…”

Section: Ovarian Stimulation In Oocyte Donorsmentioning

confidence: 99%

Time-dependent O2 consumption patterns determined optimal time ranges for selecting viable human embryos

Tejera

Herrero

Viloria

et al. 2012

Fertility and Sterility

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Sperm and oocyte donor selection and management: experience of a 10 year follow-up of more than 2100 candidates

Abstract: The screening procedure applied to all the candidates sufficiently minimizes any risk to the gamete receiver and the offspring.

Cited by 84 publications

References 5 publications

Parameters Affecting the Results in a Program of Artificial Insemination With Donor Sperm. A 12-year Retrospective Review of More Than 1800 Cycles

Parameters Affecting the Results in a Program of Artificial Insemination With Donor Sperm. A 12-year Retrospective Review of More Than 1800 Cycles

Relationship Between Standard Semen Parameters, Calcium, Cholesterol Contents, and Mitochondrial Activity in Ejaculated Spermatozoa From Fertile and Infertile Males

Time-dependent O2 consumption patterns determined optimal time ranges for selecting viable human embryos

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