Speech treatment for Parkinson's disease

Trail, Marilyn; Fox, Cynthia; Ramig, Lorraine O.; Sapir, Shimon; Howard, Julia; Lai, Eugene C.

doi:10.3233/nre-2005-20307

Cited by 98 publications

(50 citation statements)

References 148 publications

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“…This is the first study to document a qualitative change in the acoustic signal of frequencymodulated 50-kHz calls as a result of interfering with dopamine synaptic transmission in rats. These findings may be useful since speech/voice deficits are prevalent in individuals with PD and the neural mechanisms underlying speech/voice disorders in PD are unclear [1,2,17,20,45]. Bradykinesia and hypokinesia associated with PD are the most frequently implicated causes of the speech-system disorders [20,37,45] and are likely linked with dopamine depletion.…”

Section: Discussionmentioning

confidence: 99%

“…These findings may be useful since speech/voice deficits are prevalent in individuals with PD and the neural mechanisms underlying speech/voice disorders in PD are unclear [1,2,17,20,45]. Bradykinesia and hypokinesia associated with PD are the most frequently implicated causes of the speech-system disorders [20,37,45] and are likely linked with dopamine depletion. However, non-dopaminergic events, such as the depletion of non-dopaminergic neurons, cannot be ruled out [6].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Qualitative changes in ultrasonic vocalization in rats after unilateral dopamine depletion or haloperidol: A preliminary study

Ciucci

Sean

Fox

et al. 2007

Behavioural Brain Research

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106

138

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The sensorimotor speech/voice deficits associated with Parkinson disease have been well documented in humans. They are largely resistant to pharmacological and surgical treatment, but respond to intensive speech therapy. The mechanisms underlying this phenomenon are not well understood and are difficult to systematically test in humans. Thus, we turn to the rat as a model. The purpose of this study is to compare the ultrasonic vocalization (USV) of rats in three conditions: control, haloperidol-induced transient dopamine depletion, and unilateral 6-hydroxydopamine (6-OHDA) induced moderately-severe degeneration of dopamine neurons. It was hypothesized that both dopamine-altered conditions would lead to a change in the features of the USV acoustic signal. Results demonstrated that bandwidth decreased in the dopamine-altered rats. This is the first study to document a degradation of the acoustic signal of frequency-modulated 50-kHz calls as a result of interfering with dopamine synaptic transmission in rats. The data suggest that mild transient dopamine depletion with haloperidol or even unilateral degeneration of dopamine neurons is associated with changes in the USV acoustic signal. Dopaminergic dysfunction influences USV quality without reducing the number of calls. This study provides a foundation to examine the role of dopamine in sensorimotor processes underlying USV production and potentially to explore treatments for dopamine deficiency-related impaired vocal outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Qualitative changes in ultrasonic vocalization in rats after unilateral dopamine depletion or haloperidol: A preliminary study

Ciucci

Sean

Fox

et al. 2007

Behavioural Brain Research

Self Cite

106

138

View full text Add to dashboard Cite

show abstract

“…However, the combination of pharmacological and surgical treatment with behavioral speech therapy has been demonstrated to be efficient (Schulz & Grant, 2000;Spielman et al, 2011). This was supported by several reviews of the literature on the treatment of speech problems in PD patients (Sapir, Ramig, & Fox, 2011;Trail et al, 2005).…”

Section: Effects Of Dopamine Medications and Dbsmentioning

confidence: 91%

“…These effects are possibly due to the overactivation of the direct (Go) pathway of the basal ganglia, as shown by computational modeling studies (Frank, 2005). Several other studies showed that most dopamine medications were ineffective in the treatment of speech problems (Kompoliti, Wang, Goetz, Leurgans, & Raman, 2000;Larson, 1994;Trail et al, 2005), suggesting that speech problems in PD are not strongly related to dopamine dysfunction (Goberman, 2005). In agreement with this, clonazepam (a GABAergic agent) was found to significantly improve some aspects of speech in PD (Biary, Pimental, & Langenberg, 1988).…”

Section: Effects Of Dopamine Medications and Dbsmentioning

confidence: 99%

Motor symptoms in Parkinson’s disease: A unified framework

Moustafa

Chakravarthy

Phillips

et al. 2016

Neuroscience & Biobehavioral Reviews

278

156

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Parkinson's disease (PD) is characterized by a range of motor symptoms. Besides the cardinal symptoms (akinesia and bradykinesia, tremor and rigidity), PD patients show additional motor deficits, including: gait disturbance, impaired handwriting, grip force and speech deficits, among others. Some of these motor symptoms (e.g., deficits of gait, speech, and handwriting) have similar clinical profiles, neural substrates, and respond similarly to dopaminergic medication and deep brain stimulation (DBS). Here, we provide an extensive review of the clinical characteristics and neural substrates of each of these motor symptoms, to highlight precisely how PD and its medical and surgical treatments impact motor symptoms. In conclusion, we offer a unified framework for understanding the range of motor symptoms in PD. We argue that various motor symptoms in PD reflect dysfunction of neural structures responsible for action selection, motor sequencing, and coordination and execution of movement.

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“…A second homework-related difference was that the minimum number of daily homework minutes, and the total minutes of homework over the course of treatment, were substantially greater for the group intervention compared to LSVT ® . In LSVT ® , patients are asked to complete homework for 20-30 min a day on non-treatment days (divided between two sittings) and 5-10 min once on treatment days (Ramig, Countryman, O'Brien, Hoehn, & Thompson, 1996Trail et al, 2005). This results in a minimum of 320 min and a maximum of 520 min of homework over the course of 4 weeks (or 5-8.6 h).…”

Section: Delivery Of Services In a Group Formatmentioning

confidence: 99%

Feasibility of group voice therapy for individuals with Parkinson's disease

Searl

Wilson

Haring

et al. 2011

Journal of Communication Disorders

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After reading the manuscript, readers will be able to: (1) Describe previous attempts at group intervention to improve voice for individuals with Parkinson's disease. (2) List three ways that the group intervention tried in this study differed from LSVT(®). (3) Identify three limitations to this study that must be addressed before advocating implementation of the group approach in clinical situations.

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Speech treatment for Parkinson's disease

Cited by 98 publications

References 148 publications

Qualitative changes in ultrasonic vocalization in rats after unilateral dopamine depletion or haloperidol: A preliminary study

Qualitative changes in ultrasonic vocalization in rats after unilateral dopamine depletion or haloperidol: A preliminary study

Motor symptoms in Parkinson’s disease: A unified framework

Feasibility of group voice therapy for individuals with Parkinson's disease

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