PLoS ONE volume 9, issue 5, Pe98439 2014 DOI: 10.1371/journal.pone.0098439 View full text
Tracy M. Centanni, Fuyi Chen, Anne M. Booker, Crystal T. Engineer, Andrew M. Sloan, Robert L. Rennaker, Joseph J. LoTurco, Michael P. Kilgard

Abstract: In utero RNAi of the dyslexia-associated gene Kiaa0319 in rats (KIA-) degrades cortical responses to speech sounds and increases trial-by-trial variability in onset latency. We tested the hypothesis that KIA- rats would be impaired at speech sound discrimination. KIA- rats needed twice as much training in quiet conditions to perform at control levels and remained impaired at several speech tasks. Focused training using truncated speech sounds was able to normalize speech discrimination in quiet and background…

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