The effect of manipulation and distracting noise on immediate serial recall was measured in patients with dementia of the Alzheimer type (DAT), normal elderly individuals and young subjects. Experiment 1 compared serial word recall to word recall in alphabetical order. Alphabetical recall requires the active manipulation of the contents of working memory. Findings indicated that patients were severely impaired in the alphabetical recall task whereas performance of normal elderly subjects was comparable to young subjects. Experiment 2 investigated the effect of different irrelevant auditory backgrounds on immediate digit recall. In this task, both normal elderly subjects and DAT patients performed similarly to the group of young subjects, indicating comparable efficacy to resist auditory distraction. Heterogeneity of performance was assessed in the DAT patients, revealing that the alphabetical tasks yielded particularly heterogeneous performance levels. Finally, the absence of any systematic relationship between the two tasks suggests that they reflect different aspects of working memory.Key words: working memory, dementia of the Alzheimer type, manipulation, distraction, ageing
Inhibition and manipulation in DAT 3Alzheimer's disease is the major cause of dementia. As no biological marker of Alzheimer's disease currently exists, the diagnosis of dementia of the Alzheimer type (DAT) relies on extensive neurological and neuropsychological assessment. In this context, the task of the clinical neuropsychologist is to find evidence for the presence of a cognitive impairment which goes beyond that observed in the normal course of ageing.There are empirical data suggesting that working memory (WM) is impaired in DAT. WM is a short-term retention system involved in on-line processing and maintenance of information. This memory system plays a major role in numerous cognitive tasks including language comprehension, mental calculation, and the control of actions. A decrease in the span capacities of DAT patients has been reported for numerous types of material (Belleville, Peretz &, Malenfant, 1996;Corkin, 1982;Dannenbaum, Parkinson, & Inman, 1988;Hulme, Lee, & Brown, 1993; Kaszniack, Garon, & Fox, 1979;Kopelman, 1985;Morris, 1984;1987;Orsini, Trojano, Chiacchio, & Grossi, 1988;Spinnler, Della Sala, Bandera, & Baddeley, 1988).However, span is typically not very helpful in early diagnosis as it is unimpaired in early DAT patients (Corkin, 1982;Martin, Brouwers, Cox & Fedio, 1985;and Orsini et al., 1988).Other researchers have found that DAT patients are particularly impaired in WM tasks that implicate dual task coordination. DAT patients are impaired in adapted versions of the Brown-Peterson procedure Morris, 1986) whereby subjects are required to memorize letters while performing tasks of increasing difficulty (e.g.: finger tapping, articulation, digit addition). Baddeley and collaborators (Baddeley, Bressi, Della Sala, Logie & Spinnler, 1991;Baddeley, Logie, Bressi, Della Sala, & Spinnler, 1986) have used a divided...