Spectrum of ¹⁸F-FDG PET/CT Findings in Patients Presenting With Fever of Unknown Origin

Abstract

FDG PET/CT is a powerful tool in localizing an inciting source in patients with FUO. The high sensitivity of FDG PET/CT for diagnosing infective, inflammatory, and neoplastic processes can be exploited in this setting because these processes are often the common causes of FUO.

The diagnostic role of 18F fluorodeoxyglucose positron emission tomography in patients with fever of unknown origin

“…reported that FDG PET/ CT contributed not only to diagnosis but also to staging and pointing the biopsy site of the tumour . FDG PET/CT may also be helpful during evaluation of bilateral adrenal masses , or pancreatitis and FUO . In suspected temporal arteritis, the diagnostic role of FDG PET/CT is limited and is recommended that temporal artery biopsy performed prior to further evaluation of the FUO by PET/CT .…”

Fever of unknown origin: 18F-fluorodeoxyglucose positron emission tomography–computed tomography showing renal cyst infection in autosomal dominant polycystic kidney disease

“…Because of the nonspecific nature of 18 F-FDG, it is taken up by leukocytes as well as malignant cells, thereby allowing detection of a wide range of malignant, infective and inflammatory diseases which could present with FUO. [ 1 2 ] It has shown promising results for the detection of infection in renal cysts associated with ADPKD. Pijl et al .…”

“…18 F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography-computed tomography (PET-CT) is now an integral part of fever of unknown origin (FUO) management because of its ability to demonstrate the etiology in a large proportion of cases. [ 1 ] In a patient without potential diagnostic clues, 18 F-FDG PET-CT is recommended as first-line imaging. [ 2 ] Patients with autosomal dominant polycystic kidney disease (ADPKD) are at increased risk of infection because of the presence of multiple renal cysts as well as often accompanying renal dysfunction.…”

18F-fludeoxyglucose positron emission tomography computed tomography-guided diagnosis of prostatic and leptomeningeal tuberculosis

“…The same study reported a sensitivity of 90.9% and PPV of 95.2% for FDG PET-CT in cases of PUO. [ 4 ]…”