Spectrum of neurocognitive dysfunction in Indian population on FDG PET/CT imaging

Sharma, Rajnish; Tripathi, Madhavi; D’Souza, Maria; Jaimini, Abhinav; Varshney, Raunak; Panwar, Puja; Kaushik, Aruna; Saw, Sanjeev; Seher, Romana; Pandey, Santosh Kumar; Singh, Dinesh; Solanki, Yachna; Mishra, Anil K.; Mondal, Anupam; Tripathi, RP

doi:10.4103/0972-3919.90255

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…[48] AD has been found to be the most frequent form of dementia. However, a significantly higher proportion of frontal lobe involvement was noted in the Indian population, as compared to global literature.…”

Section: Neuroimagingmentioning

confidence: 99%

Dementia: Indian scenario

2012

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As per the estimates of the World Health Organization, aging population is increasing in developing countries and dementia is going to become epidemic among elderly in the coming decades. This demands early action to prevent the disease and treatment of the affected persons, which is poorly existent in middle- and low-income countries. The need of the hour to tackle dementia in India is to estimate disease burden in the community, search for risk and protective factors of dementia, and undertake measures to provide social benefits to the sufferers and those who are at risk. Raising awareness among the public and general physicians is an important task ahead. In India, there is lack of good longitudinal studies which can provide true trend of the disease and determine risk factors, paucity of basic and clinical researches on dementia, poor awareness, and inadequate availability of social benefit. India, being a country of diverse ethnicity and cultures, has great advantages to carry out genetic epidemiological study. The information may be useful for undertaking remedial measure. This article will highlight the existing state of the above medical and social issues and deficiencies, so that the stakeholders can make adequate preparation to provide relief to the dementia patients and those who are at risk. It is expected that the medical and scientific community will draw attention to the medical problem with the help of governmental and non-governmental agencies, and the political leadership will be motivated to undertake the issue of providing socioeconomic benefit to families of the victims.

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Section: Neuroimagingmentioning

confidence: 99%

Dementia: Indian scenario

2012

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“…One-hundred and twenty-nine papers were identified and screened by the referent panelist (ZW), but only 29 were selected as adequate for assessment and sent to the methodology team (see Figure 1 -PICO 8). Of these, 16 papers were excluded because i) one did not include the population of interest [26]; ii) eight did not compare DLB and AD patients [27][28][29][30][31][32][33][34]; iii) one was an epidemiologic study [35]; iv) two were methodological studies for quantitative analyses of FDG-PET [36,37]; v)…”

Section: Pico 8: Fdg-pet To Differentiate Between Dlb and Admentioning

confidence: 99%

Clinical utility of FDG-PET for the differential diagnosis among the main forms of dementia

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Altomare

Festari

et al. 2018

Eur J Nucl Med Mol Imaging

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“…A total of 101 patients were included in the final analysis. Sixty of the patients included in this study had been included in a previous analysis by our group 10 . The final diagnosis of dementia type was based on longitudinal clinical follow-up of at least 18 months at the CDM clinic, after the preliminary diagnosis of dementia by a specialist neurologist.…”

Section: Final Diagnosismentioning

confidence: 99%

Differential Diagnosis of Neurodegenerative Dementias Using Metabolic Phenotypes on F-18 FDG PET/CT

et al. 2014

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Positron emission tomography (PET) imaging with F-18 fluorodeoxyglucose (FDG) can be used as a downstream marker of neuronal injury, a hallmark of neurodegenerative dementias. Characteristic patterns of regional glucose metabolism have been used to classify the dementia subtypes, namely Alzheimer's dementia (AD), frontotemporal dementia (FTD), diffuse Lewy body (DLBD) and vascular dementia (VD). We undertook this study to assess the utility of FDG-PET in the differential diagnosis of dementia subtypes. One hundred and twenty-five patients diagnosed with dementia were referred from cognitive disorders and memory clinics of speciality neurology centres for the FDG-PET study. Imaging-based diagnosis of dementia type was established in 101 patients by visual assessment of individual scans by a PET physician blinded to the clinical diagnosis. The results were compared with an 18-month follow-up clinical assessment made by the specialist neurologist. Concordance of visual evaluation of FDG-PET scans with clinical diagnosis of the dementia type was achieved in 90% of patients scanned. This concordance was 93.4% for AD, 88.8% for FTD, 66.6% for DLBD and 92.3% for the other dementia syndromes. FDG-PET performed after the initial work-up of dementias is useful for supporting the clinical diagnosis of dementia subtype.

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Spectrum of neurocognitive dysfunction in Indian population on FDG PET/CT imaging

Cited by 5 publications

References 30 publications

Dementia: Indian scenario

Dementia: Indian scenario

Clinical utility of FDG-PET for the differential diagnosis among the main forms of dementia

Differential Diagnosis of Neurodegenerative Dementias Using Metabolic Phenotypes on F-18 FDG PET/CT

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