Spectrum of MRI Features of Mucin-producing Neoplasms in the Abdomen                     and Pelvis

Wei, Pei-Kang; Gupta, Mamta; Tsai, Leo L.; Lee, Karen; Jaramillo, Adrian M.; Smith, Martin P.; LeGout, Jordan D.; Shenoy-Bhangle, Anuradha S.

doi:10.1148/rg.210055

Cited by 9 publications

(2 citation statements)

References 71 publications

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“…The SI of the cystic component may be indicative of the cystic content, such as the concentration of proteinaceous, mucinous, and hemorrhagic material. 23-25 Our results suggest that pseudoprogression tends to occur in cystic VS presenting a lower SI of the cystic component in T2WI and a higher SI of the cystic component in CET1WI, both of which suggest “thick” proteinaceous or hemorrhagic cystic material (as opposed to clear material). However, the pathophysiology of this is yet to be elucidated.…”

Section: Discussionmentioning

confidence: 71%

Association Between Pseudoprogression of Vestibular Schwannoma After Radiosurgery and Radiological Features of Solid and Cystic Components

et al. 2023

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BACKGROUND AND OBJECTIVES: The pathophysiology of vestibular schwannoma (VS) pseudoprogression after Gamma Knife radiosurgery (GKRS) remains unclear. Radiological features in pretreatment magnetic resonance images may help predict VS pseudoprogression. This study used VS radiological features quantified using an automated segmentation algorithm to predict pseudoprogression after GKRS treatment. METHODS: This is a retrospective study comprising 330 patients with VS who received GKRS. After image preprocessing and T2W/contrast-enhanced T1-weighted image (CET1W) image generation, with fuzzy C-means clustering, VSs were segmented into solid and cystic components and classified as solid and cystic. Relevant radiological features were then extracted. The response to GKRS was classified into “nonpseudoprogression” and “pseudoprogression/fluctuation”. The Z test for two proportions was used to compare solid and cystic VS for the likelihood of pseudoprogression/fluctuation. Logistic regression was used to assess the correlation between clinical variables and radiological features and response to GKRS. RESULTS: The likelihood of pseudoprogression/fluctuation after GKRS was significantly higher for solid VS compared with cystic VS (55% vs 31%, P < .001). For the entire VS cohort, multivariable logistic regression revealed that a lower mean tumor signal intensity (SI) in T2W/CET1W images was associated with pseudoprogression/fluctuation after GKRS (P = .001). For the solid VS subgroup, a lower mean tumor SI in T2W/CET1W images (P = .035) was associated with pseudoprogression/fluctuation after GKRS. For the cystic VS subgroup, a lower mean SI of the cystic component in T2W/CET1W images (P = .040) was associated with pseudoprogression/fluctuation after GKRS. CONCLUSION: Pseudoprogression is more likely to occur in solid VS compared with cystic VS. Quantitative radiological features in pretreatment magnetic resonance images were associated with pseudoprogression after GKRS. In T2W/CET1W images, solid VS with a lower mean tumor SI and cystic VS with a lower mean SI of cystic component were more likely to have pseudoprogression after GKRS. These radiological features can help predict the likelihood of pseudoprogression after GKRS.

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Section: Discussionmentioning

confidence: 71%

Association Between Pseudoprogression of Vestibular Schwannoma After Radiosurgery and Radiological Features of Solid and Cystic Components

et al. 2023

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“…Several clinical studies have shown that high T1 signals (T1 shortening) are detected in high concentrations of macromolecules, such as in mucin-containing tumors (Gaeta et al, 2002). The oligosaccharides attached to the peptide chains within the thick mucin causes T1 shortening either by themselves or through water-macromolecule interactions, which can increase T1 signal intensity within tumors (Wei et al, 2022). Histopathological analysis revealed PAS-positive effusions in the interstitium of the testes of busulfan-treated mice.…”

Section: Discussionmentioning

confidence: 99%

Development of a non-invasive method for testicular toxicity evaluation using a novel compact magnetic resonance imaging system

Yokota

Miyaso

Hirai

et al. 2022

Preprint

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In non clinical animal studies for drug discovery, histopathological evaluation is the most powerful tool to assess testicular toxicity. However, histological analysis is extremely invasive; many experimental animals are needed to evaluate changes in the pathology and anatomy of the testes over time. As an alternative, small animal magnetic resonance imaging (MRI) offers a non invasive methodology to examine testicular toxicity without radiation. The present study demonstrated the suitability of a new, ready to use compact MRI platform using a high field permanent magnet to assist with the evaluation of testicular toxicity. To validate the utility of the MRI platform, male mice were treated with busulfan (40 mg/kg, intraperitoneal injection). Tenty eight days after treatment, both testes in busulfan-treated and control mice (n = 3/group) were non-invasively scanned in situ by MRI at 1 tesla. On a T1-weighted, 3D gradient echo MRI sequences (voxel size: 0.23 x 0.23 x 0.50 mm), the total testicular volume in busulfan-treated mice was significantly smaller than in controls. On T1 weighted images, the signal intensity of the testes was significantly higher in busulfan treated mice than in controls. The mice were sacrificed, and the testes were isolated for histopathological analysis. The weight of the testes in busulfan treated mice significantly decreased, similar to the results of the non-invasive analysis. Additionally, periodic acid-Schiff stain positive effusions were observed in the interstitium of the busulfan treated mouse testes, potentially explaining T1 shortening due to a high concentration of glycoproteinaceous content. The present data demonstrated a rapid evaluation of testicular toxicity in vivo by compact MRI.

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