Spectrum of HIV/AIDS related cancers in India

Abstract

The absence of Kaposi's sarcoma and increased PIRs for certain non-AIDS defining cancers among HIV infected cancer cases indicates a different spectrum of HIV associated malignancies in this region. The raised PIR for cervical cancer emphasizes the urgent need for screening programs for cervical cancer among HIV infected individuals in India.

Cancer in cohort of HIV-infected population: prevalence and clinical characteristics

“…Cancers occurred at a much younger age in HIV-infected population (42 years) than that in HIV-negative population. This conforms to the observation in other parts of the world (Sriplung and Parkin 2004;Dhir et al 2008;Jermal et al 2009) and points towards the hypothesis that HIV infection indeed shortens the latent period observed in the progression of premalignant cervical lesions to invasive disease.…”

Epidemiology of Lymphoid Malignancy in Asia

“…The underlying reason for this unique feature of AIDS-related lymphoma in Thailand is not known and further investigation is needed (Sukpanichnant, et al, 1998). In one study in India the proportional incidence ratio (PIR) for NHL was significantly increased in HIV era (PIR in males = 17.1, 95%CI 13.33-21.84, females = 10.3, 95%CI 6.10-17.41), and their finding was similar to that reported by other studies (Dhir, et al, 2008). In one study in Singapore when comparing the age-standardized rates for males and female in 1998 -2002 which are 8.2 and 5.0 per 100,000 respectively compared with 7.5 and 4.4 per 100,000 in 1993-1997 and 3.1 and 1.9 per 100,000 in 1968-1972, this may be partly due to HIV/AIDS, changes in pathological classification and improved diagnostic capabilities (Seow & Registry, 2004).…”

Cancer in Human Immunodeficiency Virus Patients- A Study From a Regional Cancer Centre

“…5 The incidence of malignancy in HIV patients is higher than general population, as they are more prone for maligancy. [1][2][3][4] The spectrum of malignancies in our study is different from that noted in other studies, which were also single institute studies. Majority of the Indian patients with ADCs or NADCs were males 6 in previous studies, but in our study majority 61% of the patients were females (115/189).…”