Spectrum of Diabetic Neuropathy: New Insights in Diagnosis and Treatment

Dillon, Brendan R.; Ang, Lynn; Pop-Busui, Rodica

doi:10.1146/annurev-med-043021-033114

Cited by 9 publications

(2 citation statements)

References 67 publications

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“…For this reason, it is uncertain how Bell's palsy and these CMRs are related; either the detectable CMRs are causes or merely associated disorders of Bell's palsy. However, it was suggested that the prediabetes state was possibly an associated disorder with Bell's palsy, especially among those who have characteristics of MS or a personal history of diabetes risks [2,37,38]. Moreover, a study of the genetic association between HT and Bell's palsy also reported that HT was a significant risk of Bell's palsy at the genetic level, whereas DM and lipid disorders required further studies for confirmation [39].…”

Section: Discussionmentioning

confidence: 99%

Association between Bell’s Palsy and Cardiometabolic Risks: An Age- and Sex-Matched Case–Control Study

Mueanchoo,

Tepparak,

Chongphattararot

et al. 2024

JPM

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Background: Bell’s palsy is possibly an ischemic cranial neuropathy, although reactivation of herpes virus infection has been proposed. Methods: This was an age-and sex-matched and 1:2 case–control study enrolling Bell’s palsy patients during 2011–2021 in a university hospital to investigate the significant associations of cardiometabolic risks (CMRs) with Bell’s palsy. We analyzed the differences in waist circumference (WC), body mass index (BMI), systolic and diastolic blood pressures (SBP and DBP), fasting blood sugar (FBS), and lipid levels at 12 weeks post-Bell’s palsy with those of the controls by descriptive statistics (p < 0.05). The differences in means or medians of individual CMR values across the consecutive 10-year age intervals were analyzed by ANOVA F-tests and Kruskal–Wallis tests (p < 0.05). Results: A total of 140 cases and 280 controls were enrolled. Bell’s palsy patients had significantly higher WC, BMI, SBP, DBP, FBS, and triglyceride but lower high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). Moreover, high WC, elevated FBS (≥100 mg/dL), SBP (≥130 mmHg), and total cholesterol were significantly associated with Bell’s palsy cases by multivariable analysis. Only FBS in Bell’s palsy patients significantly elevated across consecutive 10-year age intervals. Conclusion: Screening and monitoring for CMRs, especially hyperglycemia, in every patient presenting with Bell’s palsy is essential despite initial normoglycemia, particularly in older-onset cases.

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Section: Discussionmentioning

confidence: 99%

Association between Bell’s Palsy and Cardiometabolic Risks: An Age- and Sex-Matched Case–Control Study

Mueanchoo,

Tepparak,

Chongphattararot

et al. 2024

JPM

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“…autonomic dysfunction, however, affects the autonomic nervous system that regulates involuntary bodily functions. This dysfunction contributes to various problems, such as cardiovascular dysfunction characterized by blood pressure and heart rate changes, gastrointestinal dysfunction leading to gastroparesis, and urogenital dysfunction affecting bladder control and sexual function ( 2 ). DPN alone contributes to more than $10 billion in annual healthcare expenses, exceeding one-fourth of the total direct medical costs of diabetes ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

The causal relationship between gut microbiota and diabetic neuropathy: a bi-directional two-sample Mendelian randomization study

Xie,

Gan,

Cai

2024

Front. Endocrinol.

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BackgroundMany studies suggest a strong correlation between gut microbiota (GM) and diabetic neuropathy (DN). However, the precise causal relationship between GM and DN has yet to be fully elucidated. Hence, a bi-directional Mendelian randomization (MR) analysis was used to examine the association between GM and DN.MethodsWidely known genome-wide association study (GWAS) of GM was collected from the MiBio Gen project. Summary-level datasets for DN were taken from the FinnGen project. Inverse variance weighted approach was used for evaluating the causal relationship between GM and DN. Subsequently, pleiotropy and heterogeneity tests were performed to verify the reliability of the data. Furthermore, a bidirectional two-sample MR analysis was done to investigate the directionality of the causal relationships. Gene Ontology analysis was conducted to identify the associations that could indicate biological functions.ResultsWe identified potential causal associations between GM and DN (p< 0.05 in all three MR methods). Among them, we found increased levels of Christensenellaceae R-7 (Odds ratio, OR= 1.52; 95% confidence interval, CI = 1.03–2.23; p = 0.03), Ruminococcaceae UCG013 (OR =1.35; 95% CI = 1.00–1.85; p = 0.04), and Eggerthella groups (OR = 1.27; 95% CI = 1.05–1.55; p = 0.01), which may be associated with a higher risk of DN, while increased levels of Peptococcaceae (OR = 0.69; 95% CI = 0.54–0.90; p< 0.01) and Eubacterium coprostanoligenes groups (OR = 0.68; 95% CI = 0.49–0.93; p = 0.01) could be associated with a lower risk. Gene Ontology pathway analysis revealed enrichment of genes regulated by the associated single-nucleotide polymorphisms (SNPs) in the apical plasma membrane, glycosyltransferase activity, hexosyltransferase activity and membrane raft. Reverse MR analyses indicated that DN was associated with five microbial taxa in all three MR methods.ConclusionThe results of our study validate the possible causative relationship between GM and DN. This discovery gives new perspectives into the mechanism on how GM influences DN, and establishes a theoretical foundation for future investigations into targeted preventive measures.

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Attenuation of PI3K/AKT signaling pathway by Ocimum gratissimum leaf flavonoid-rich extracts in streptozotocin-induced diabetic male rats

Ajiboye,

Famusiwa,

Amuda

et al. 2024

Biochemistry and Biophysics Reports

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Spectrum of Diabetic Neuropathy: New Insights in Diagnosis and Treatment

Cited by 9 publications

References 67 publications

Association between Bell’s Palsy and Cardiometabolic Risks: An Age- and Sex-Matched Case–Control Study

Association between Bell’s Palsy and Cardiometabolic Risks: An Age- and Sex-Matched Case–Control Study

The causal relationship between gut microbiota and diabetic neuropathy: a bi-directional two-sample Mendelian randomization study

Attenuation of PI3K/AKT signaling pathway by Ocimum gratissimum leaf flavonoid-rich extracts in streptozotocin-induced diabetic male rats

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