Spectrum of chronic gastrointestinal diseases with final outcome in children at a tertiary care centre: a single-centre study

Seerat, Iqtadar; Atique, Muhammad; Khan, E.

doi:10.47391/jpma.3546

Cited by 1 publication

(1 citation statement)

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“…Chronic low back pain is linked to elevated risks of anxiety and depression, especially in females [27]. Severe depression is associated with total health care costs in chronic pain patients even when controlling for key demographic, functional, and clinical covariates, and effective treatment of depression may improve functional health of patients and attenuate the impact of chronic pain on health care [28].…”

Section: Discussionmentioning

confidence: 99%

Depression Predicts Chronic Pain Interference in Racially Diverse, Income-Disadvantaged Patients

et al. 2021

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Background Chronic pain is one of the most common reasons adults seek medical care in the US, with prevalence estimates ranging from 11% to 40%. Mindfulness meditation has been associated with significant improvements in pain, depression, physical and mental health, sleep, and overall quality of life. Group medical visits are increasingly common and are effective at treating myriad illnesses, including chronic pain. Integrative Medical Group Visits (IMGV) combine mindfulness techniques, evidence based integrative medicine, and medical group visits and can be used as adjuncts to medications, particularly in diverse underserved populations with limited access to non-pharmacological therapies. Objective and Design The objective of the present study was to use a blended analytical approach of machine learning and regression analyses to evaluate the potential relationship between depression and chronic pain in data from a randomized clinical trial of IMGV in diverse, income disadvantaged patients suffering from chronic pain and depression. Methods The analytical approach used machine learning to assess the predictive relationship between depression and pain and identify and select key mediators, which were then assessed with regression analyses. It was hypothesized that depression would predict the pain outcomes of average pain, pain severity, and pain interference. Results Our analyses identified and characterized a predictive relationship between depression and chronic pain interference. This prediction was mediated by high perceived stress, low pain self-efficacy, and poor sleep quality, potential targets for attenuating the adverse effects of depression on functional outcomes. Conclusions In the context of the associated clinical trial and similar interventions, these insights may inform future treatment optimization, targeting, and application efforts in racialized, income disadvantaged populations, demographics often neglected in studies of chronic pain. Trial Registration NCT from clinicaltrials.gov: 02262377

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Section: Discussionmentioning

confidence: 99%