Spectrum of Cervical Cytological Lesions in Premenopausal and Postmenopausal Women

Nagose, Vaishali Baburao; Halder, Nirvana Rasaily; Deshpande, S.A.; Rathod, Shivanand Shriram; Jadhav, Varsha Ashok

doi:10.21276/apalm.1661

Cited by 1 publication

(4 citation statements)

References 6 publications

(11 reference statements)

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“…Although rapid stain in the form of toluidine blue has been very rarely used in Pap smear, we tried to compare our study with few other studies. Studies done by Atilgan et al [21] (2.1%) and Nagose et al [6] (2.71%) had near about similar US rates as our study 2.4%. However, the number of cases in their study was 32,026 and 6,647 respectively, which is very high compared to our study without the implementation of ROSE [6, 21].…”

Section: Discussionsupporting

confidence: 89%

“…Studies done by Atilgan et al [21] (2.1%) and Nagose et al [6] (2.71%) had near about similar US rates as our study 2.4%. However, the number of cases in their study was 32,026 and 6,647 respectively, which is very high compared to our study without the implementation of ROSE [6, 21]. The regular implementation of ROSE will help in further reduction of US rates.…”

Section: Discussionsupporting

confidence: 89%

“…In cervico-vaginal cytology, the implementation of toluidine blue has been limitedly used [6, 21]. Our study was to evaluate the helpful staining properties of toluidine blue in mass screening for inflammatory lesions and SIL lesions.…”

Section: Discussionmentioning

confidence: 99%

“…The quality of cervical cytology screening can be assessed by quality indices such as relative percentages of the various diagnoses, including the unsatisfactory (US) rate and the atypical squamous cells(ASC) to squamous intraepithelial lesion (SIL) ratio [3,5]. The correlation of cytological diagnosis with available histological follow-up allows the evaluation of false-positive and false-negative cases [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Applicability of On-Site Evaluation of Cervical Cytology Smears Stained with Toluidine Blue to Reduce Unsatisfactory Results

2022

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Introduction: Carcinoma of the uterine cervix is a major health problem faced by Indian women. Screening techniques like visual inspection with acetic acid, Lugol’s iodine, Papanicolaou smear, and human papillomavirus DNA testing have been suggested. Pap smear is a simple, safe, cost-effective, and reliable technique used for screening cervical lesions. Rapid on-site evaluation (ROSE) using the 1% aq. toluidine blue staining method has been less studied in cervical cytology. Materials and Methods: Our study was a prospective study done over a period of 2 years. All the cervical cytology smears were reported as per the Bethesda system 2014. Rapid stain using aqueous toluidine blue (1%) and conventional Pap stain was done on the smears received. Results: We evaluated a total of 1,300 cases, with 97.6% satisfactory samples. The spectrum of cases included 96.3% of negative for malignancy cases (including bacterial vaginosis, trichomonas, candida, and atrophic smears), atypical squamous cell of undetermined significance and atypical squamous cells cannot exclude high-grade squamous intraepithelial lesion in 0.5% cases, low-grade squamous intraepithelial lesion and high-grade intraepithelial lesion in 0.3% cases, squamous cell carcinoma in 0.3% cases, and atypical glandular cells/adenocarcinoma in 0.2% cases. Turnaround time was within 48 h in 77% cases. With rapid stain, our unsatisfactory rate was reduced from 12% to approx. 2.4%. Conclusion: ROSE has been attempted on routine FNA cytology samples with success. However, the use of ROSE in cervical cytology has not been attempted to date. Lower unsatisfactory rate is an important indicator for the successful implementation of cervical cancer screening technique.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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