Spectrum of biopsy-proven renal diseases: A single center experience

Gopaliah, Lakshminarayana R; Sudakaran, Indu; Seethalekshmy, NV; Narayanan, Ranjit; Vareed, Biju Meckattuparamban

doi:10.4103/1319-2442.229295

Cited by 3 publications

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“…It is an accurate and gold-standard tool for diagnosing glomerular diseases and determining the prognosis of patients. Furthermore, immunofluorescence (IF) studies provide additional information for histopathological analysis [ 7 ]. Currently, almost 99.9% of biopsies are diagnostic and result in an accurate diagnosis [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Morphological Spectrum of Glomerulonephritis in Medical Renal Biopsies: A Single-Center Study

Rafique¹,

Sadaf²,

Batool³

et al. 2022

Cureus

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BackgroundGlomerulonephritis is among the most common and serious non-communicable diseases in the world, and some of them are major causes of chronic kidney disease, which eventually leads to kidney failure. In developing countries, it is the most common cause of end-stage renal disease (ESRD). Chronic kidney disease affects 10-16% of the adult population in Asia, including 21.2% in Pakistan. This study aims to determine the frequency and spectrum of glomerulonephritis at our center. MethodologyThis is a cross-sectional analysis of 81 renal core biopsies obtained between August 2020 and August 2021. The histopathological reports, demographic data, and relevant laboratory investigations, such as blood urea and creatinine levels, were collected. All cases were blindly reviewed by two pathologists with a special interest in medical renal pathology. Data were analyzed using SPSS version 22 (IBM Corp., Armonk, NY, USA). ResultsThe majority of the patients (46.9%) were between the ages of 21 and 40 years. There was a slight male predominance, with 44 (54.3%) of the 81 participants being male. Hematuria was reported in 20 (24.7%) patients, with mean serum urea and creatinine levels of 75 mg/dL and 2.6 mg/dL, respectively. Nephrotic syndrome was the most common indication for a renal biopsy, accounting for 54 (67.7%) of the 81 cases. Chronic glomerulonephritis is classified into two categories, namely, primary and secondary glomerulonephritis. Focal segmental glomerulosclerosis (FSGS), the leading cause of primary glomerulonephritis, was found in 25 (30.9%) 81 patients. Furthermore, lupus nephritis (9.9%) and advanced glomerulonephritis (9.9%) were found in equal proportions among secondary glomerulonephritis. ConclusionsAccording to our study, nephrotic syndrome was the most common indication for medical renal biopsy, with FSGS being the most common primary glomerulonephritis. Lupus nephritis and advanced glomerulonephritis were the most common secondary glomerulonephritis diagnoses.

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Section: Introductionmentioning

confidence: 99%

Morphological Spectrum of Glomerulonephritis in Medical Renal Biopsies: A Single-Center Study

Rafique¹,

Sadaf²,

Batool³

et al. 2022

Cureus

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The role of kidney biopsy in deciphering diabetic versus non-diabetic origin of kidney disease among patients with type 2 diabetes mellitus and nephrotic range proteinuria: A retrospective study

Kardalas,

Paikopoulou,

Vassiliadi

et al. 2024

Metabolism Open

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Spectrum of Glomerular Diseases in North India and its Clinicopathological Correlation – An Observational Study

Sharma,

Singh,

Sood

et al. 2023

Journal of Marine Medical Society

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Introduction: Glomerular diseases (GDs) have varied presentations in adults. The spectrum varies from benign to aggressive presentations. Materials and Methods: We conducted an observational prospective study at a tertiary care teaching hospital in North India from July 2020 to June 2022 to evaluate GD’s spectrum and clinicopathological correlation. All kidney biopsies conducted during this period were considered as per inclusion and exclusion criteria, and detailed history and clinical examination were done. Results: One hundred and twenty-six kidney biopsies were evaluated as per inclusion and exclusion criteria. The mean age was 37.77 ± 17.73 years. Overall, the male-to-female ratio was 2.3:1 while the male-to-female ratio in lupus nephritis (LN) is 0.37:1. Primary GD (PGD) dominated among males whereas secondary GD (SGD) was more common in females. Nephrotic syndrome (NS, 44.5%) and acute kidney injury 27% were the most common clinical syndromes. The most common symptoms were edema and frothuria in NS (70%), and hematuria in acute nephritic syndrome 59%, whereas fatigue and gastrointestinal symptoms (44%) dominated in SGDs. The PGD-to-SGD ratio was 61.1:38.9. The most common PGD was immunoglobulin A nephropathy (IgAN, 22.1%), followed by minimal change disease (MCD, 20.8%), whereas LN (22.5%) was the prominent SGD, with Class IV + V (36.4%) being most common. Conclusion: GDs have a multitude of presentations – from asymptomatic urinary abnormalities to crescentic ones. IgAN and MCD were the most common of PGD whereas LN was the most common SGD.

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Spectrum of biopsy-proven renal diseases: A single center experience

Cited by 3 publications

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Morphological Spectrum of Glomerulonephritis in Medical Renal Biopsies: A Single-Center Study

Morphological Spectrum of Glomerulonephritis in Medical Renal Biopsies: A Single-Center Study

The role of kidney biopsy in deciphering diabetic versus non-diabetic origin of kidney disease among patients with type 2 diabetes mellitus and nephrotic range proteinuria: A retrospective study

Spectrum of Glomerular Diseases in North India and its Clinicopathological Correlation – An Observational Study

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