Spectrum of Alcohol-Induced Myocardial Damage Detected by Indium-111–Labeled Monoclonal Antimyosin Antibodies

Ballester, Manel; Martı́, Vicens; Carrió, Ignasi; Obrador, D; Moya, C; Pons-Lladó, Ġuillem; Bernà, Lluı́s; Lamich, Rubén; Aymat, María R.; Barbanoj, Manel J.; Guardia, Josep; Carreras, Francesc; Udina, C; Augé, Josep M.; Marrugat, Jaume; Permanyer, Gaietà; Caralps-Riera, J M

doi:10.1016/s0735-1097(96)00425-1

Cited by 29 publications

(8 citation statements)

References 48 publications

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“…Beyond its effects on measures of atherosclerosis or atherosclerotic risk factors (7), the effects of alcohol on the myocardium are unclear. While prolonged high levels of alcohol consumption (>100 grams/day >10 years) have been associated with overt myocardial damage (8), it is yet to be determined if cardiac damage occurs at lower levels of alcohol consumption.…”

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confidence: 99%

Alcohol Consumption and Cardiac Biomarkers: The Atherosclerosis Risk in Communities (ARIC) Study

et al. 2016

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Background The role of alcohol in the development of subclinical cardiovascular disease is unclear. We examined the association between alcohol consumption and markers of subclinical cardiac damage and wall stress. Methods We studied the cross-sectional and prospective associations of alcohol consumption with high-sensitivity cardiac troponin (hs-cTnT) and N-terminal pro B-type natriuretic peptide (NT-proBNP) measured at two time points, 6 years apart (baseline, 1990-1992; follow-up, 1996-1998), in over 11,000 participants of the Atherosclerosis Risk in Communities (ARIC) Study with no history of cardiovascular disease. Alcohol was categorized as: never, former, current: ≤1, 2-7, 8-14, and ≥15 drinks/week. Results Compared to never drinkers, persons who consumed 2-7 drinks per week were less likely to have increased hs-cTnT (≥ 14 ng/L) at baseline (OR= 0.67, 95%CI 0.46-0.96), and had a lower risk of incident increases in hs-cTnT at follow up (RR=0.70, 95%CI 0.49-1.00). Conversely, there was a positive association between alcohol intake and NT-proBNP concentrations at baseline. Consumption of ≥15 drinks/week was positively associated with incident increases in NT-proBNP (≥300 pg/mL) at the 6-year follow-up visit (RR=2.38, 95%CI 1.43-3.96). Conclusion In this community-based study of middle-aged adults without a history of cardiovascular disease, moderate drinking was associated with lower concentrations of hs-cTnT, a marker of chronic subclinical myocardial damage, and positively associated with NT-proBNP, a biomarker of cardiac wall stress. Our results suggest that the cardiac effects of alcohol are complex. Cardiac biomarkers may help improve our understanding of the full cardiovascular effects of alcohol consumption.

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confidence: 99%

Alcohol Consumption and Cardiac Biomarkers: The Atherosclerosis Risk in Communities (ARIC) Study

et al. 2016

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“…Ballester explained these discrepancies by the fact that LV function results in the combination of different factors: the degree of recent myocyte necrosis (detected by AM imaging), the amount of fibrotic tissue (myocardial mass loss not detected by AM imaging), and the proportion of purely functionally impaired myocardium 25. In systemic diseases, myocyte death may be of ischaemic origin (injury of the microvessels), or related to cytotoxic immune pathways.…”

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confidence: 99%

111Indium antimyosin antibody imaging of primary myocardial invovement in systemic diseases

Sarda

Assayag

Palazzo

et al. 1999

Annals of the Rheumatic Diseases

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Objective-The diagnosis of primary myocardial involvement in systemic diseases is clinically relevant but diYcult in the absence of specific criteria. Whatever the underlying disease, myocytes degeneration is observed during the active phase of myocardial damage. The aim of this study was to assess the diagnostic value of scintigraphic imaging with Primary cardiac involvement in systemic diseases carries a poor prognosis and has important therapeutic implications.

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“…It is predicted that when this type of myocardial imaging becomes commercially available, it would provide a sensitive screening tool for exclusion of myocardial necrosis. The specificity of this test, however, will remain low because the high affinity of the tracer for necrotic myocytes would lead to a positive scan in any condition associated with myocardial necrosis (21)(22)(23)(24).…”

Section: Indium-111mentioning

confidence: 99%

Cardiovascular imaging in clinical and experimental acute infectious myocarditis

et al. 2003

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Acute myocarditis can be caused by a variety of organisms. Congestive heart failure and death may occur as a consequence of these infections. In recent years cardiac imaging, by echocardiography and magnetic resonance and nuclear imaging has become a useful adjunct in the diagnosis and management of infectious myocarditis. Specific examples of their usefulness will be given in the discussions of chagasic myocarditis, bacterial myocarditis, acquired immunodeficiency syndrome and peripartum cardiomyopathy. Finally, we explore the exciting area of cardiac imaging of small animals, such as mice infected with Trypanosoma cruzi.

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Spectrum of Alcohol-Induced Myocardial Damage Detected by Indium-111–Labeled Monoclonal Antimyosin Antibodies

Cited by 29 publications

References 48 publications

Alcohol Consumption and Cardiac Biomarkers: The Atherosclerosis Risk in Communities (ARIC) Study

Alcohol Consumption and Cardiac Biomarkers: The Atherosclerosis Risk in Communities (ARIC) Study

111Indium antimyosin antibody imaging of primary myocardial invovement in systemic diseases

Cardiovascular imaging in clinical and experimental acute infectious myocarditis

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