Spectrum effect correlation of yangyin tongnao granules on cerebral ischemia-reperfusion injury rats

Zhang, Yangyang; Yu, Li; Yang, Jiehong; Ding, Zhishan; Wan, Haitong

doi:10.3389/fphar.2022.947978

Cited by 2 publications

(2 citation statements)

References 42 publications

(33 reference statements)

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“…GRA is a method to study the degree of similarity or dissimilarity of development trends among factors. It is used to measure the degree of association between different factors and to evaluate the degree of correlation between the components and pharmacological effects of traditional Chinese medicine (Xiao et al, 2022 ; Yang et al, 2022 ; Zhang, Yu, Yang, et al, 2022 ). In this study, pharmaceutical factors correlating with spleen deficiency from CRC samples with different storage years were used as the mother sequence, and each characteristic peak quantification index was used as the sub‐sequence.…”

Section: Methodsmentioning

confidence: 99%

Flavonoids contribute most to discriminating aged Guang Chenpi (Citrus reticulata ‘Chachi’) by spectrum‐effect relationship analysis between LC‐Q‐Orbitrap/MS fingerprint and ameliorating spleen deficiency activity

Sun,

Deng,

Shan

et al. 2023

Food Science & Nutrition

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To further explore the mechanism of “the longer storage time, the better bioactivity” of aged Guang Chenpi, the dry pericarp of Citrus reticulata ‘Chachi’ (CRC), a series of activity assessments were performed on spleen deficiency mice. The constituents in CRC with different storage years were analyzed by LC‐Q‐Orbitrap/MS. A total of 53 compounds were identified, and CRC stored for more than 5 years showed higher flavonoid content, especially that of polymethoxyflavones. Anti‐spleen deficiency bioactivity analysis among various CRC with different storage years showed aged CRC (stored for more than 3 years) could significantly alleviate fatigue and depression behaviors much better, increase D‐xylose and gastrin secretion, and upregulate the expression of the linking protein occludin in the colon walls. Results from 16S rDNA sequencing showed that aged CRC could downregulate the abundance of Enterococcus, Gemmata, Citrobacter, Escherichia_Shigella, and Klebsiella, which were significantly overrepresented in the model group. Bacteroides, Muribaculum, Alloprevotella, Paraprevotella, Alistipes, Eisenbergiella, and Colidextribacter were downregulated in the model group but enriched in the CRC groups. At last, the spectrum‐effect relationship analysis indicated that flavonoids such as citrusin III, homoeriodictyol, hesperidin, nobiletin, and isosinensetin in aged CRC showed the highest correlation with better activity in ameliorating spleen deficiency by regulating gut microbiota. Flavonoids contribute most to discriminating aged CRC and could disclose the basis of “the longer storage time, the better bioactivity” of aged Guang Chenpi.

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Section: Methodsmentioning

confidence: 99%

Flavonoids contribute most to discriminating aged Guang Chenpi (Citrus reticulata ‘Chachi’) by spectrum‐effect relationship analysis between LC‐Q‐Orbitrap/MS fingerprint and ameliorating spleen deficiency activity

Sun,

Deng,

Shan

et al. 2023

Food Science & Nutrition

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“…Zhang et al determined the plasma fingerprints of rats with middle cerebral artery occlusion dosed with Yangyin Tongnao Granules at different time points by HPLC. They detected the changes in the levels of inflammatory factors under medicated plasma at different time points [103]. Six components correlate with the inflammation index by studying spectrum-effect relationships.…”

Section: Exploration Of Drug-containing Serum Of Tcmmentioning

confidence: 99%

Spectrum–Effect Relationships as an Effective Approach for Quality Control of Natural Products: A Review

He,

Zhang,

Yang

et al. 2023

Molecules

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As natural products with biological activity, the quality of traditional Chinese medicines (TCM) is the key to their clinical application. Fingerprints based on the types and contents of chemical components in TCM are an internationally recognized quality evaluation method but ignore the correlation between chemical components and efficacy. Through chemometric methods, the fingerprints represented by the chemical components of TCM were correlated with its pharmacodynamic activity results to obtain the spectrum–effect relationships of TCM, which can reveal the pharmacodynamic components information related to the pharmacodynamic activity and solve the limitations of segmentation of chemical components and pharmacodynamic research in TCM. In the 20th anniversary of the proposed spectrum–effect relationships, this paper reviews its research progress in the field of TCM, including the establishment of fingerprints, pharmacodynamic evaluation methods, chemometric methods and their practical applications in the field of TCM. Furthermore, the new strategy of spectrum–effect relationships research in recent years was also discussed, and the application prospects of this technology were discussed.

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Spectrum effect correlation of yangyin tongnao granules on cerebral ischemia-reperfusion injury rats

Cited by 2 publications

References 42 publications

Flavonoids contribute most to discriminating aged Guang Chenpi (Citrus reticulata ‘Chachi’) by spectrum‐effect relationship analysis between LC‐Q‐Orbitrap/MS fingerprint and ameliorating spleen deficiency activity

Flavonoids contribute most to discriminating aged Guang Chenpi (Citrus reticulata ‘Chachi’) by spectrum‐effect relationship analysis between LC‐Q‐Orbitrap/MS fingerprint and ameliorating spleen deficiency activity

Spectrum–Effect Relationships as an Effective Approach for Quality Control of Natural Products: A Review

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