Spectrum and Presentation of Urinary Bladder Growth: a Single-Center Retrospective Study

Paudel, Deliya; Regmi, Himanshu; Bajracharya, Uspal Bahadur; Shrestha, Gulshan Bahadur

doi:10.3126/nmj.v4i2.42055

Cited by 3 publications

(3 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…UCB incidence show difference between the sexes. We saw a significantly increased diagnosis rate in male patients, most bladder cancers (87.1%) were recorded in males, this is in agreement with other study (Paudel et al, 2021) with male to female ratio was 4.67. The possible causes for that difference are thought to be different exposure levels to environmental carcinogens, genetic differences, differences in hormonal balance, anatomical differences, social life differences (Türk et al, 2017), where smoking always related to men in our society.…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

Urinary Bladder Cancer-Epidemiological and Histopathological Study

Awad¹,

AL-Agori²,

Yaya³

et al. 2023

IJMRA

View full text Add to dashboard Cite

Urinary bladder cancer is the main reason for morbidity and mortality throughout the world. Urothelial carcinoma is a common primary tumor of urinary bladder (90%). To investigate the epidemiological and histopathological aspects in Libyan patients suffering from urinary bladder cancer, we performed a study on 39 bladder cancer biopsies from transurethral resection of bladder tumor (TURBT) and cystoscopic samples obtained from Oncology Department- Al Hawari Hospital, over the period of (2021- May 2022), Tiba Medical Laboratory (2021- July 2022), and Alnoon Medical laboratory (2019- January 2022) at Benghazi, Libya. Of the 39 cases, 34 (87.2%) were diagnosed in men, and 5 (12.8%) were found in women, the men/ women ratio being of 6.8/1. The highest incidence of bladder tumors was recorded in individuals aged between 61 and 80 years old. In this age group, there were admitted 24 patients with bladder cancer, representing 61.5%. The most common pathological types of urinary bladder carcinoma found was Invasive Urothelial Carcinoma TCC (48.72%) followed by noninvasive Urothelial Carcinoma TCC (46.15%), and Squamous Cell Carcinoma SCC in (5.13%). A case of SCC on top of Schistosomiasis was also seen. Grade III was found in 51.2% of our patients and 43.5% of them had stage II. This study has highlighted upon the importance of histopathological study in evaluating urinary bladder cancer. Cystoscopic studies and biopsies help in early detection of bladder neoplasms and they form the mainstay of the diagnosis and follow up. The objects of this work were to assess epidemiological features of the bladder cancer in Benghazi - Libya with regard to frequency, age and sex distribution. Furthermore, to describe the Histopathological features of the urinary bladder cancer, particularly Transitional Cell Carcinoma (TCC) in urinary bladder biopsies.

show abstract

Section: Discussionsupporting

confidence: 93%

“…Approximately 90% of malignant tumors are transitional cell carcinomas. The remaining 10% comprises all other types of carcinomas (Paudel et al, 2021). In this study too, transitional cell carcinoma is the most common bladder tumor (94.8%), while squamous cell carcinoma constitutes (5.1%) of 39 bladder tumors seen over a multi-year period.…”

Section: Discussionmentioning

confidence: 61%

Urinary Bladder Cancer-Epidemiological and Histopathological Study

Awad¹,

AL-Agori²,

Yaya³

et al. 2023

IJMRA

View full text Add to dashboard Cite

show abstract

“…Similar to our results, the study done by Paudel et al also show similar age range of 60-80 years. 11 However, in other studies done by Shah et al 1 Pokar and Prasanna et al 5 the commonest age of presentation was sixth decade of life. The bladder tumors are thought to be commonly found in elderly population because of treatment related toxicity secondary to medical comorbidities with poor immune response.…”

Section: Discussionmentioning

confidence: 89%

Spectrum of Lesions in the Urinary Bladder: A Histopathological Study in a Tertiary Level Hospital

Poudel,

Ranabhat,

Shahi

et al. 2023

J Coll Med Sci-Nepal

View full text Add to dashboard Cite

Background: Urinary Bladder cancer is the 7th most common cancer worldwide, with an estimated 260,000 new cases occurring each year in men and 76,000 in women. 90% of the bladder tumors are of urothelial origin. Cystoscopic examination has a limited role in staging process for which transurethral resection (TURBT) of visible tumor down to the base is required which can accurately assess depth of tumor invasion. Aim & Objectives: The aim is to study the spectrum of urinary bladder lesions according to World Health Organization / International Society of Urological Pathology consensus classification and to determine age and sex distribution of urothelial tumors. Material & Method: Study included 55 TURBT specimens, conducted over a period 12 months, extending from January 2022 to December 2022. Hematoxylin & Eosin (H&E) stained sections were examined for morphologic diagnosis of urothelial lesions. Results: In our study, there was male preponderance with ratio of 3.2:1. Among 55 cases studied, 34.55% cases were diagnosed as invasive urothelial carcinoma, 27.27% cases were of non-invasive urothelial carcinoma, 16.36% cases were of benign urothelial neoplasm and 16.36% cases were of non-neoplastic lesions in urinary bladder. There were also 1.82% cases of adenocarcinoma, metastasis and non-diagnostic each in our study. Amongst invasive carcinoma high grade were encountered most (30.91%) cases. Maximum numbers of urothelial neoplasms (25.45%) were seen in 71-80 years of age group. Conclusion: This study revealed that neoplastic lesions are more common than non-neoplastic lesions. Urothelial tumors are seen commonly in seventh decade with overall male predominance. Also this study, documents a high frequency of invasive than non-invasive type of urothelial neoplasm.

show abstract

Exploring the Histopathological Landscape of Urinary Bladder Diseases: A Tertiary Care Center Study

Kundlia,

Dharwadkar,

Gore

et al. 2024

Cureus

View full text Add to dashboard Cite

Introduction Urinary bladder lesions encompass a wide spectrum, from benign inflammatory conditions to malignant neoplasms, presenting diagnostic and therapeutic challenges. Urothelial carcinoma predominates among bladder malignancies, exhibiting diverse clinical presentations and prognoses. Objective This study aimed to delineate the histopathological spectrum of urinary bladder lesions and correlate demographic profiles, clinical features, and cystoscopic findings with various bladder lesions. Methods This prospective descriptive observational study spanned 24 months at a tertiary care center, involving 65 cases of urinary bladder biopsies, including transurethral resection of bladder tumors, cystoscopic biopsies, and cystectomy specimens. The histopathological examination followed the WHO 2022 classification of urinary bladder tumors and the American Joint Committee on Cancer eighth edition staging. Clinical data, including age, gender, cystoscopic findings, and presenting symptoms, were correlated with histopathological diagnoses to explore the spectrum of bladder lesions. Results Neoplastic lesions predominated, constituting 92.3% of cases, with urothelial carcinoma comprising 83.33% of these cases. Among neoplastic lesions, invasive high-grade urothelial carcinoma (36.7%) and non-invasive low-grade papillary urothelial neoplasm (20.0%) were the most frequently observed subtypes. Non-neoplastic lesions accounted for 7.7%, including various forms of cystitis. Hematuria was the predominant presenting symptom (81.5%), while cystoscopic examinations revealed that most lesions were situated in the lateral bladder wall. High-grade urothelial carcinomas were mostly associated with muscularis propria invasion. Conclusion This study underscores the critical role of histopathological examination in diagnosing and managing urinary bladder diseases and distinguishing between non-neoplastic and neoplastic lesions. Urothelial carcinoma, prevalent among older age groups, often demonstrated muscle invasion indicative of high-grade tumors. Including the muscle layer in cystoscopic biopsies is crucial for an accurate diagnosis. Conversely, though less common, non-neoplastic conditions encompass various forms of cystitis. These findings highlight the importance of precise diagnostic tools such as cystoscopy and histopathological examination for the early detection and management of bladder neoplasms. Histopathological assessment offers essential prognostic guidance, aids in precise staging and grading, and directs tailored treatment strategies.

show abstract

Spectrum and Presentation of Urinary Bladder Growth: a Single-Center Retrospective Study

Cited by 3 publications

References 3 publications

Urinary Bladder Cancer-Epidemiological and Histopathological Study

Urinary Bladder Cancer-Epidemiological and Histopathological Study

Spectrum of Lesions in the Urinary Bladder: A Histopathological Study in a Tertiary Level Hospital

Exploring the Histopathological Landscape of Urinary Bladder Diseases: A Tertiary Care Center Study

Contact Info

Product

Resources

About