Spectrum and Outcome of Noninfectious Aortitis

Abstract

Objective To assess the spectrum and long-term outcome of patients with noninfectious aortitis. Methods We performed a retrospective multicenter study of 353 patients (median age at diagnosis was 62 [IQR 46–71] yrs and 242 [68.6%] patients were women) with noninfectious aortitis. Factors associated with vascular complications were assessed in multivariate analysis. Results We included 136 patients with giant cell arteritis (GCA), 96 with Takayasu arteritis (TA), 73 with clinically isolated aortitis (CIA), and 48 with aortitis secondary to inflammatory diseases (including Behçet disease, relapsing polychondritis, IgG4-related disease, Cogan syndrome, ankylosing spondylitis). After a median follow-up of 52 months, vascular complications were observed in 32.3%, revascularizations in 30% of patients, and death in 7.6%. The 5-year cumulative incidence of vascular complications was 58% (95% CI 41–71), 20% (95% CI 13–29), and 19% (95% CI 11–28) in CIA, GCA, and TA, respectively. In multivariate analysis, male sex (HR 2.10, 95% CI 1.45–3.05, P < 0.0001) and CIA (HR 1.76, 95% CI 1.11–2.81, P = 0.02) were independently associated with vascular complications. Conclusion Noninfectious aortitis accounts for significant morbidity and mortality. CIA seems to carry the highest rate of vascular complications.

Navigating the Challenges of Takayasu Arteritis in a 26-Year-Old Female With Recurrent Chest Pain and a Complex Medical History

“…The diagnosis of TA requires a high index of suspicion and a multifaceted approach, relying heavily on a combination of clinical evaluation, laboratory findings, and imaging modalities [ 5 , 11 ]. Angiography, including CT angiography and magnetic resonance angiography, plays a central role in identifying characteristic features such as arterial stenosis, occlusion, and vascular wall thickening, providing insights into vascular inflammation and damage [ 3 , 12 ].…”

Relationship between histopathological features of non-infectious aortitis and the results of pre-operative 18F-FDG-PET/CT: a retrospective study of 16 patients

“…Clinically isolated aortitis (CIA) represents a particular subset that is limited to the aorta without signs of systemic disease, although some cases may evolve to GCA (1). Rarely, aortitis may be a complication of rheumatic diseases such as ankylosing spondylitis or relapsing polychondritis (2). Aortitis is associated with significant morbidity and potential mortality related to aneurysmal dilatation, aortic dissection, or rupture (3)(4)(5)(6).…”