Spectroscopic, thermal, catalytic and biological studies of Cu(II) azo dye complexes

Synthesis, structural characterization and molecular modelling of bidentate azo dye metal complexes: DNA interaction to antimicrobial and anticancer activities

“…The overall order of the observed cytotoxicity was HL > C4 > C2 > C3 > C1. Such behaviour is also reported in the literature for related azo dye compounds, while complexation of the azo dye with metal ions decreases the activity towards inhibition of cancer cell growth . Comparison of the IC 50 values for the compounds under study with those for reported azo dyes and their chelates against the same tested cell line and under the same experimental conditions revealed that the compounds under study are more active as anticancer agents against HEPG2 cell line .…”

“…Such behaviour is also reported in the literature for related azo dye compounds, while complexation of the azo dye with metal ions decreases the activity towards inhibition of cancer cell growth . Comparison of the IC 50 values for the compounds under study with those for reported azo dyes and their chelates against the same tested cell line and under the same experimental conditions revealed that the compounds under study are more active as anticancer agents against HEPG2 cell line . The most important finding in this case is the significant cell growth inhibition activity of the azo dye ligand itself (IC 50 = 4.58 μg ml −1 ), which is very close to the IC 50 value of the standard anticancer drug doxorubicin.…”

“…A comparative study between the antimicrobial activity of the azo dye ligand under study and that of the related Schiff base ligand 5‐mercapto‐1,2,4‐triazole‐3‐imine‐2′‐hydroxynaphthalene that has the same amine and aldehyde moieties revealed that the azo dye ligand is slightly less active against the same bacterial and fungal strains and under the same experimental conditions . On the other hand, a comparison between the antimicrobial activity of the azo dye ligand under study and its chelates and that of other reported azo dye ligands and their complexes indicated that the compounds reported here demonstrated, to some extent, higher activity against the same tested microbial strains . Other reported azo dye metal complexes exhibited higher activity comparing with the compounds under study …”

2,4‐Dihydroxy‐5‐[(5‐mercapto‐1H‐1,2,4‐triazole‐3‐yl)diazenyl]benzaldehyde acetato, chloro and nitrato Cu(II) complexes: Synthesis, structural characterization, DNA binding and anticancer and antimicrobial activity

“…Transition metal complexes have been utilized in the area of drug design. Thus, special attention has been paid to the interaction between transition metal complexes and DNA …”

“…Cu(II) is recognized as an environmental contaminant that can lead to damage of microorganisms and of cancer cells in the human body . Many scientists have concentrated their research work on transition metal chelates of azo compounds due to their biological and catalytic applications …”