Spectroscopic studies on Zn(II)-phthalocyanine in homogeneous and microheterogeneous systems

In vivo fluorescence and photodynamic activity of zinc phthalocyanine administered in liposomes

“…Drug-carrier system Zn(II) phthalocyanine (Ciba-Geigy, Basle, Switzerland) incorporated into small unilamellar liposomes was prepared as previously described (Valduga et al, 1987 (Figure 1). In this pilot study rhodamine was used as the lasing dye because fluorescence was the primary objective.…”

Liposome- or LDL-administered Zn (II)-phthalocyanine as a photodynamic agent for tumours. I. Pharmacokinetic properties and phototherapeutic efficiency

“…Previous analysis of the compound showed a degree of purity of 97% (Valduga et al, 1987 Drug preparation Zn-Pc was incorporated into small unilamellar vesicles of DPPC following the procedure described by Valduga et al (1987). For these experiments liposomes were prepared in 0.9% aqueous NaCl and before injection they were dialysed for 3 h against 250 ml of NaCl with a change of the NaCl solution after the first hour.…”

“…The latter are very hydrophobic compounds and can be used in vivo only after their inclusion into lipid matrices. We have reported a procedure for the incorporation of Zn-Pc into small unilamellar vesicles of DPPC (Valduga et al, 1987). The photosensitising efficiency of this phthalocyanine in vitro has also been documented (Valduga et al, 1988).…”

Pharmacokinetic studies with zinc(II)-phthalocyanine in tumour-bearing mice

“…Sublimation of the sample under high vacuum showed a degree of purity of 97% (Valduga et al, 1987 Pharmacokinetic studies The Zn-Pc was injected-i.p. into tumour-bearing mice after incorporation of the dye into small unilamellar liposomes of DPPC following the procedure described by Valduga et al (1987): The Zn-Pc/DPPC ratio was 1:36 on a molar basis, as assessed from the weighed amount of phospholipid and absorbance measurements at 680 nm for Zn-Pc (E= 1.68 x 105 M-1 cm-at 673 nm). The injected dose of Zn-Pc was 0.5mg kg -mouse body wt.…”

“…Such water-insoluble dyes can be transported in the bloodstream via unilamellar liposomes (Valduga et al, 1987); the latter carriers were shown to induce an efficient targeting of experimental tumours by water-insoluble porphyrins (Jori et al, 1983), possibly through the preferential delivery of the incorporated drug to serum lipoproteins (Jori, 1985). In this paper, we describe the pharmacokinetic behaviour of liposome-bound Znphthalocyanine injected into.…”