Spectroscopic studies on the interaction of morin–Eu(III) complex with calf thymus DNA

Zhang, Guowen; Guo, Jinbao; Pan, Jun-hui; Chen, Xiuxia; Wang, Junjie

doi:10.1016/j.molstruc.2009.02.011

Cited by 94 publications

(38 citation statements)

References 44 publications

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“…The thermodynamic parameters show the binding mode [24]. If the binding enthalpy change (∆H) is invariant over a small temperature range [25] the standard molar binding enthalpy (∆H m Ө ), is estimated from the relationship:…”

Section: Thermodynamic Parametersmentioning

confidence: 99%

<b>Synthesis and DNA interaction of a Sm(III) complex of a Schiff base derived from vanillin and L-tryptophan</b>

Wang

Zhang

Zhao

et al. 2011

Bull. Chem. Soc. Eth.

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Section: Thermodynamic Parametersmentioning

confidence: 99%

<b>Synthesis and DNA interaction of a Sm(III) complex of a Schiff base derived from vanillin and L-tryptophan</b>

Wang

Zhang

Zhao

et al. 2011

Bull. Chem. Soc. Eth.

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“…In other words, DNA protected vitamin K 3 from the quenching effect of the solvent molecules, so the emission intensity of vitamin K 3 increased noticeably. 17 The curve of the fluorescence intensity versus the DNA/K 3 molar ratio was plotted at 524 nm (Fig. 4), allowing us to obtain the binding ratios between vitamin K 3 and herringsperm DNA as n DNA : n K3 ¼ 1 : 2.…”

Section: Resultsmentioning

confidence: 99%

Interactions of Vitamin K₃ with Herring-Sperm DNA Using Spectroscopy and Electrochemistry

et al. 2010

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By means of ultraviolet-visible (UV-Vis) and fluorescence spectra, the binding ratio between vitamin K3 and herring-sperm DNA in a physiological pH environment (pH = 7.40) was determined as nK3: nDNA = 2:1, and the binding constants of vitamin K3 binding to DNA at different temperatures were determined as Kθ298K = 1.28 × 105 L.mol−1 and Kθ310K = 7.19 × 104 L.mol−1, which were confirmed using the double reciprocal method are ΔrHmθ = −3.57 × 104 J.mol−1, ΔrGmθ = −2.92 × 104 J.mol−1, and ΔrSmθ = 217.67 J.mol−1K−1. The driving power of this process was enthalpy. An intercalation binding of the vitamin K3 with DNA was supported by a competitive experiment using acridine orange (AO) as a spectral probe. By combination analysis of the Scatchard method and cyclic voltammetry, we suggested that the interaction mode between vitamin K3 and herring-sperm DNA would be a mixed mode. The quinonoid, duality fused-ring of vitamin K3 can intercalate into the base pairs of DNA, and there is an electrostatic binding along with intercalation binding.

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“…Binding of DNA via the intercalative mode usually results in significant hypochromicity (#40 %) and red shift (.10 nm), [21,22] because the intercalation involves a strong stacking interaction between an aromatic chromophore and the DNA base pairs. [23] However, external groove binding causes a small (or no) spectral shift and an occasional hyperchromicity. The absorption spectra of ADNRS in the absence and presence of ctDNA are shown in Fig.…”

Section: Absorption Spectra Studiesmentioning

confidence: 99%

Spectroscopic and Modelling Analysis on the Interaction of 3'-Azidodaunorubicin Semicarbazone with ctDNA

et al. 2014

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The synthesis and characterisation of a new anthracycline, 3 0 -azidodaunorubicin semicarbazone (ADNRS) is reported. The interaction between ADNRS and calf thymus DNA (ctDNA) was investigated by absorption and fluorescence spectroscopy in combination with melting temperature (T m ) curves and molecular modelling in physiological buffer (pH 7.4). Evidence indicates that ADNRS binds in the groove of ctDNA and the fluorescence quenching mechanism is a static quenching type. Calculated thermodynamic parameters show that hydrophobic interactions may play a predominant role in the binding. Furthermore, molecular modelling results corroborate the spectroscopic investigations.

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Spectroscopic studies on the interaction of morin–Eu(III) complex with calf thymus DNA

Cited by 94 publications

References 44 publications

<b>Synthesis and DNA interaction of a Sm(III) complex of a Schiff base derived from vanillin and L-tryptophan</b>

<b>Synthesis and DNA interaction of a Sm(III) complex of a Schiff base derived from vanillin and L-tryptophan</b>

Interactions of Vitamin K₃ with Herring-Sperm DNA Using Spectroscopy and Electrochemistry

Spectroscopic and Modelling Analysis on the Interaction of 3'-Azidodaunorubicin Semicarbazone with ctDNA

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Spectroscopic studies on the interaction of morin–Eu(III) complex with calf thymus DNA

Cited by 94 publications

References 44 publications

<b>Synthesis and DNA interaction of a Sm(III) complex of a Schiff base derived from vanillin and L-tryptophan</b>

<b>Synthesis and DNA interaction of a Sm(III) complex of a Schiff base derived from vanillin and L-tryptophan</b>

Interactions of Vitamin K3 with Herring-Sperm DNA Using Spectroscopy and Electrochemistry

Spectroscopic and Modelling Analysis on the Interaction of 3'-Azidodaunorubicin Semicarbazone with ctDNA

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Interactions of Vitamin K₃ with Herring-Sperm DNA Using Spectroscopy and Electrochemistry