Spectroscopic studies on the interaction between chalcone and bovine serum albumin

Investigation into the interaction of methylparaben and erythromycin with human serum albumin using multispectroscopic methods

“…The contour map shows a bird's eye view of the fluorescence spectra. In Figs and S7, peak a is the Rayleigh scattering peak (λ ex = λ em ) . On addition of methylparaben or erythromycin, the fluorescence intensities of peak a increased.…”

Comparative studies on the interactions of baicalein and Al(III)–baicalein complex with human serum albumin

“…Peak I ( λ ex = 280.0 nm, λ em = 346.0 nm) shows the spectral characteristic of Trp and Tyr residues. When HSA is excited at 280 nm, the intrinsic fluorescence of Trp and Tyr residues are displayed, whereas fluorescence by the Phe residue is negligible . Peak II ( λ ex = 225.0 nm and λ em = 343.0 nm) exhibits the fluorescence characteristics of polypeptide backbone structures, and this peak is correlated with the secondary protein structure .…”

Interactions of Three Chalcones with Human Serum Albumin Revealed by Spectroscopic Techniques

“…The binding affinities of three chalcones with HSA at pH 7.4 were ranked in the order (the binding constants in the range 0.28 -2.39 × 10 5 L mol biological activity, such as antibacterial, antifungal, anticancer and anti-inflammatory properties. [8][9][10][11] The anticancer activity of chalcones is primarily ascribed to its phenolic hydroxyl groups that exhibit high affinity to proteins and thus could inhibit the growth of cancer cells. Chalcones that exist in licorice root can restrain the proliferation of established and primary ovarian cancer cells.…”