Spectroscopic Studies of Proton Transfer Equilibria In Hydrogen Bonded Complexes

Habeeb, Moustafa M.

doi:10.1080/05704929508001134

Cited by 27 publications

(11 citation statements)

References 54 publications

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“…6F is the appearance of new vibrational bands at 515, 538, 567, 590 cm À1 , respectively. These bands are presumably attributed to the formation of NHN hydrogen bonding beside OHN one in AMTD-CHA complex [48]. 7.…”

Section: Ftir Spectramentioning

confidence: 95%

Synthesis and spectroscopic studies of charge transfer complexes between chloranilic acid and some heterocyclic amines in ethanol

Al-Attas

Habeeb

Al-Raimi

2009

Journal of Molecular Structure

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Section: Ftir Spectramentioning

confidence: 95%

Synthesis and spectroscopic studies of charge transfer complexes between chloranilic acid and some heterocyclic amines in ethanol

Al-Attas

Habeeb

Al-Raimi

2009

Journal of Molecular Structure

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“…IR and NMR spectroscopy often offer experimental proofs to directly indicate the formation of ion pairs, and they are especially pronounced for hydrogen-bonded ion pairs (Barthel and Deser 1994;Biliškov et al 2011;Habeeb 1997;Pregosin 2009). Such intermolecular interaction can be qualitatively inferred from the spectral characteristics.…”

Section: The Confirmation Of Ion-pair Formationmentioning

confidence: 99%

Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

Dragićević¹,

Maibach²

2015

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“…FTIR has already been utilized in many researches to confirm the formation of ion-pairs (Habeeb, 1997;Arunan et al, 2011;Xi et al, 2012). As shown in Figure 5, LOXO showed two strong narrow peak around 1708 and 1733 cm À1 .…”

Section: Evidence Of Ion-pair Formationmentioning

confidence: 99%

The effect of ion-pair formation combined with penetration enhancers on the skin permeation of loxoprofen

et al. 2014

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Context: Loxoprofen (LOXO) is a non-steroidal anti-inflammatory drug. Repeated oral administrations induce gastrointestinal side effects. Patches are a promising alternative. Objective: The aim of this study was to investigate the effects of organic amines on the skin permeation of LOXO and finally design a patch with a comparable permeation profile and pharmacodynamic effects to the commercial LOXONA Õ plaster. Materials and methods: The effects of organic amines were assessed by flux values of LOXO from isopropyl myristate (IPM), using horizontal diffusion cell and rabbit skin. FTIR spectroscopy was used to confirm ion-pair formation. Anti-inflammatory and analgesic activity assessments were performed in the adjuvant arthritis rat model and acetic acid-induced writhing syndrome in mouse, separately. Results and discussion: Results showed that triethylamine (TEA) was the most potential candidate in IPM, with the highest flux of 499.75 ± 32.40 mg/cm 2 /h. In patch, the highest flux of 369.37 ± 34.32 mg/cm 2 /h was still obtained by LOXO-TEA. Combined with penetration enhancers, the cumulative amounts were further increased in presence of 5% IPM, which exhibited a flux of 840.04 ± 66.38 mg/cm 2 /h as two times of the commercial one. Ultimately, anti-inflammatory and analgesic activity assessment presented that a comparable pharmacodynamic activity with the commercial one could be obtained by the patch we designed. Additionally, we also found that LOXO patch applied topically exerted a systemic effect, and the effect was dose-dependent. Conclusion: It was feasible for LOXO patch design by combination of ion-pair technology and chemical enhancers.

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Spectroscopic Studies of Proton Transfer Equilibria In Hydrogen Bonded Complexes

Cited by 27 publications

References 54 publications

Synthesis and spectroscopic studies of charge transfer complexes between chloranilic acid and some heterocyclic amines in ethanol

Synthesis and spectroscopic studies of charge transfer complexes between chloranilic acid and some heterocyclic amines in ethanol

Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

The effect of ion-pair formation combined with penetration enhancers on the skin permeation of loxoprofen

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