Spectroscopic studies and x-ray crystal structure determination of the complex cis-(S-ethylcysteine)platinum(II)dichloride

Kinetic Studies on the Reactions of Different Bifunctional Platinum(II) Complexes with Selected Nucleophiles

“…The complexes [Pt(SMC)Cl 2 ] (isolated in the protonated form from 0.1 m HCl), [Pt(en)Cl 2 ] and [Pt(dach)Cl 2 ] were prepared according to published procedures. [34][35][36] Elemental analysis, 1 H NMR and UV/Vis spectra of these complexes were in good agreement with the previously obtained data. Cisplatin, cis-[Pt(NH 3 ) 2 -Cl 2 ], was purchased from Aldrich.…”

Structures of dichloro[(S)-methionine-N,S]platinum(II) and chloro[glycyl-(S)-methioninato-N,N',S]platinum(II) monohydrate

“…Both diastereomers have the thioether methyl group [C(5),C(10)] in an axial orientation, but the respective S--C bonds lie on opposite sides of the ring (see scheme). The Pt--S bond lengths, 2.246 (2) and 2.247 (2)A, are not significantly different from the values of 2.244 (2) ]k in dichloro-(R,S)-ethionineplatinum(II) (Khan et al, 1991) and 2.218 (8), 2.260(7)A in dichloro-(S)-ethylcysteineplatinum(II) (Theodorou et al, 1982). In both molecules of (I) the Pt--CI bond distance trans to S [2.323(2), 2.320 (2) …”

“…0108-2701/92/061012-04506.00 the platinum(II) complexes of ethylcysteine (Theodorou, Photaki, Hadjiliadis, Gellert & Bau, 1982), ethionine (Khan, Venkatasubramanian, Najmuddin, Shamsuddin & Zakeeruddin, 1991) and thioglycine (Zahn, Polborn & Beck, 1989) have been reported recently. The structures of dichloro-(S)-methionineplatinum(II), (I), and of chloroglycl-(S)-methioninatoplatinum(II) monohydrate, (II), were reported in a preliminary publication by Freeman & Golomb (1970).…”

Equilibrium Studies of Complex Formation Reactions of [Pd (SMC)(H2O)2] + with Amino Acids, Peptides or DNA Constituent

“…: C, 14.52; H, 3.32; N, 4.24 %.) The complex was converted in solution into the diaqua form by treating it with two equivalents of AgNO 3 , as described elsewhere (13)(14)(15) .…”