Spectroscopic, single crystal X-ray, Hirshfeld, in vitro and in silico biological evaluation of a new series of potent thiazole nucleus integrated with pyrazoline scaffolds

N-(4-Nitrophenyl)-2-{2-[3-(4-chlorophenyl)-5-[4-(propan-2-yl)phenyl]-4,5-dihydro-1H-pyrazol-1-yl]-4-oxo-4,5-dihydro-1,3-thiazol-5-yl}acetamide

“…The synthesis and crystal structure of the starting material, 3-(4-chlorophenyl)-5-[4-(propan-2-yl) phenyl]-4,5-dihydro-1H-pyrazole-1-carbothioamide (1) was described in our earlier work [15][16][17].…”

Formation of 1-(thiazol-2-yl)-4,5-dihydropyrazoles from simple precursors: synthesis, spectroscopic characterization and the structures of an intermediate and two products

“…The synthesis and crystal structure of a new thiazolyl-pyrazoline derivative bearing the 1,2,4-triazole moiety has been reported (CSD refcode BAKLOQ; Zeng et al, 2012). A new series of 1,3thiazole integrated pyrazoline scaffolds have been synthesized and characterized (DADQIL, DADQEH; Salian et al, 2017). The synthesis, fluorescence, TGA and crystal structure of a thiazolyl-pyrazoline derived from chalcones has been described (JUNRAN; Suwunwong et al, 2015).…”

Unveiling a versatile heterocycle: pyrazoline – a review

“…Although studies on pyrazoline derivatives have been carried out for several years, researchers are still looking for novel pyrazoline compounds possessing biological activities. [131][132][133][134][135][136][137][138] Indoxacarb is the rst commercialized pyrazoline-type sodium-channel blocker insecticide, testifying to the importance of optimizing pyrazoline-type chemistry with regards to insecticidal efficacy, safety towards non-target organisms and the environment. 139,140 There are some groups that have adopted the molecular hybridization method to explore pyrazoline-type insecticides in an attempt to enhance environmental degradation, reduce bioaccumulation, and improve efficacy.…”