“…1,2,7,26,31,34 A relatively weak carbon signal at δ = −8.3 ppm can also be observed, indicating the partitioning of small amounts of CH 4 molecules in the large (sII-L, 5 12 6 4 ) cages of sII hydrates. 1,2,7,26,31,34 Similar to the structural transition of ethylamine crystalline hydrate (cubic sI hydrate with a space group of Pm-3n) into the cubic sII hydrate with help gas, CPrA can form sII hydrate in the presence of CH 4 gas. 41 In the absence of CH 4 gas, CPrA molecules is expected to be captured in the large (sI-L, 5 12 6 2 ) cages of sI hydrate (Figure 3); thus, CPrA in the large (sI-L, 5 12 6 2 ) cages of sI hydrate may have strong host−guest interactions via hydrogen bonding.…”