Spectroscopic Methods in Solid‐state Characterization

Strachan, Clare J.; Saarinen, Jukka; Lipiäinen, Tiina; Vuorimaa‐Laukkanen, Elina; Rautaniemi, Kaisa; Laaksonen, Timo; Skotnicki, Marcin; Dračínský, Martin

doi:10.1002/9781119414018.ch2

Cited by 4 publications

(2 citation statements)

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“…(Müllertz et al, 2016)) and articles review one or a subset of the available solid-state analysis techniques in a pharmaceutical context (e.g. spectroscopy (Strachan et al, 2020), and several overviews of all the most commonly used techniques are also available (Chieng et al, 2011;Pindelska et al, 2017;Ma and Williams, 2019). An overview of the more widely available solid-state analysis techniques is presented in Table 1, together with some theoretical features and practical issues.…”

Section: Characterization Of Ordermentioning

confidence: 99%

Degrees of order: A comparison of nanocrystal and amorphous solids for poorly soluble drugs

Peltonen

Strachan

2020

International Journal of Pharmaceutics

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Poor aqueous solubility is currently a prevalent issue in the development of small molecule pharmaceuticals. Several methods are possible for improving the solubility, dissolution rate and bioavailability of Biopharmaceutics Classification System (BCS) class II and class IV drugs. Two solid state approaches, which rely on reductions in order, and can theoretically be applied to all molecules without any specific chemical prerequisites (compared with e.g. ionizable or co-former groups, or sufficient lipophilicity), are the use of the amorphous form and nanocrystals. Research involving these two approaches is relatively extensive and commercial products are now available based on these technologies. Nevertheless, their formulation remains more challenging than with conventional dosage forms. This article describes these two technologies from both theoretical and practical perspectives by briefly discussing the physicochemical backgrounds behind these approaches, as well as the resulting practical implications, both positive and negative. Case studies demonstrating the benefits and challenges of these two techniques are presented.

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Section: Characterization Of Ordermentioning

confidence: 99%

Degrees of order: A comparison of nanocrystal and amorphous solids for poorly soluble drugs

Peltonen

Strachan

2020

International Journal of Pharmaceutics

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“…Solid-state NMR (SSNMR) spectroscopy is a non-destructive, powerful technique for obtaining structural and dynamic information on solid pharmaceutical systems [38][39][40] and is especially useful for characterizing amorphous solids [38,41,42] since standard Bragg diffraction techniques are of little value for materials lacking long-range order. NMR spectroscopy is the method of choice to study tautomerism [19,43], since it is directly sensitive to H locations.…”

Section: Introductionmentioning

confidence: 99%