Spectroscopic investigation on protein damage by ciprofloxacin under ultrasonic irradiation

Liu, Bin; Wang, Dong-Jing; Wang, Xin; Liu, Bing-Mi; Kong, Yifan; He, Lihua; Wang, Jun; Xu, Shukun

doi:10.1016/j.saa.2010.11.054

Cited by 14 publications

(5 citation statements)

References 37 publications

(37 reference statements)

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“…Under US irradiation, numerous organic molecules are being found to possess sonodynamic effects, especially inspired by the antecedent PDT, more and more organic sonosensitizers have been derived from organic photosensitizers. Wherein, the photosensitive porphyrins (e.g., protoporphyrin IX, hematoporphyrin, and hematoporphyrin monomethyl ether) and their derivatives (e.g, Ce6) have been commonly employed in the SDT studies, ,− other organic molecules including typical xanthenes (e.g., erythrosine B and rose bengal), ,− indocyanines (e.g., ICG and IR780), − anticancer drugs (e.g., doxorubicin and quinolone antibiotics), − hypocrellin B, − and 5-aminolevulinic acid, − also have exhibited relatively high SDT efficiencies. − Table summarizes the representative category of organic sonosensitizers in recent years. By comparison, there are many distinct benefits to using organic sonosensitizers in SDT.…”

Section: Sonosensitizersmentioning

confidence: 99%

Metal–Organic Frameworks (MOF)-Assisted Sonodynamic Therapy in Anticancer Applications

Yang

Dong

et al. 2023

ACS Nano

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Sonodynamic therapy (SDT) has emerged as a promising therapeutic modality for anticancer treatments and is becoming a cutting-edge interdisciplinary research field. This review starts with the latest developments of SDT and provides a brief comprehensive discussion on ultrasonic cavitation, sonodynamic effect, and sonosensitizers in order to popularize the basic principles and probable mechanisms of SDT. Then the recent progress of MOF-based sonosensitizers is overviewed, and the preparation methods and properties (e.g., morphology, structure, and size) of products are presented in a fundamental perspective. More importantly, many deep observations and understanding toward MOF-assisted SDT strategies were described in anticancer applications, aiming to highlight the advantages and improvements of MOF-augmented SDT and synergistic therapies. Last but not least, the review also pointed out the probable challenges and technological potential of MOF-assisted SDT for the future advance. In all, the discussions and summaries of MOF-based sonosensitizers and SDT strategies will promote the fast development of anticancer nanodrugs and biotechnologies.

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Section: Sonosensitizersmentioning

confidence: 99%

Metal–Organic Frameworks (MOF)-Assisted Sonodynamic Therapy in Anticancer Applications

Yang

Dong

et al. 2023

ACS Nano

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“…Liu et al reported that CPFX in the presence of US could produce ROS and damage BSA. [92] Other physical factors such as ultrasonic time, ambient temperature, and ionic strength also affect the damage degree of BSA. Dong et al explored the killing effect of LVFX combined with US irradiation on M. smegmatis and its sonodynamic antibacterial mechanism.…”

Section: Fluoroquinolone Antibioticsmentioning

confidence: 99%

“…reported that CPFX in the presence of US could produce ROS and damage BSA. [ 92 ] Other physical factors such as ultrasonic time, ambient temperature, and ionic strength also affect the damage degree of BSA. Dong et al.…”

Section: Organic Small Molecule Sonosensitizersmentioning

confidence: 99%

Organic Sonosensitizers for Sonodynamic Therapy: From Small Molecules and Nanoparticles toward Clinical Development

Yang

et al. 2021

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Some acoustically active substances can combine with specific molecules/cells and enable imaging of complex disease processes at the molecular level. [8,9] In parallel, accumulating evidence demonstrates that US is an appealing regimen for managing various diseases including Alzheimer's diseases, cardiovascular diseases, and cancers. [10][11][12][13] According to the frequency, US is usually categorized into high intensity focused US (HIFU; >200 kHz) and low intensity focused US (LIFU; 20-200 kHz). [14] HIFU enables truly non-invasive tumor ablation in clinical applications. [15] There have been tens of thousands of cases reporting HIFU guided by US or magnetic resonance imaging to treat solid organ tumors globally. [16,17] However, recent investigations indicate that the administration of HIFU can lead to adverse events such as skin burn and nerve injury. [18] Theoretically, LIFU with lower intensity can eliminate US-induced overheating and make the treatment safer. LIFU radiation combined with sonosensitizer administration (sonodynamic therapy, SDT), was developed as a suitable therapy alternative by Yumita et al. in 1989. [19] When US activates the preloaded sonosensitizers, they can trigger sensitive reactions to produce reactive oxygen species (ROS), which play a therapeutic role in specific sites through different mechanisms. [20,21] More importantly, due to the excellent regional focusing characteristics and strong tissue penetrating ability of US, SDT has higher therapeutic efficiency and fewer side effects. [22,23] Recent intriguing investigations had been carried out using SDT to treat cancer, cardiovascular disease, and multidrug-resistant (MDR) bacterial infection. [24] Notably, SDT of cancer and atherosclerotic peripheral artery disease (PAD) has been applied in clinical trials, and the results showed high efficacy and favorable safety on patients. [25,26] The sonosensitization efficiency, ROS quantum yield, and accumulation of the sonosensitizers in the target cells are essential prerequisites for SDT. [27,28] Therefore, designing and developing excellent sonosensitizers is an important topic in the development of SDT. Generally, sonosensitizers mainly include organic and inorganic sonosensitizers. Many inorganic sonosensitizers have superior physiochemical properties, but the clinical translation remains unresolved because of nonbiodegradation and potential biosafety issues. However, organic sonosensitizers have the advantages of clear structure and easy metabolism, which is conducive to clinical applications. [24] Sonodynamic therapy (SDT) is a novel noninvasive therapeutic modality that combines low-intensity ultrasound and sonosensitizers. Versus photomediated therapy, SDT has the advantages of deeper tissue penetration, high accuracy, and less side effects. Sonosensitizers are critical for therapeutic efficacy during SDT and organic sonosensitizers are important because of their clear structure, easy monitoring, evaluation of drug metabolism, and clinical transformation. Notably, nanotechnolo...

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“…SDT has been shown to be effective against most bacteria. Ciprofloxacin (CIP), a fluoroquinolone antibacterial drug, has remarkable sonosensitivity [25]. It is possible to reuse older antibiotics in novel nano-based drug delivery systems [26].…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-Launched Targeted Nanoparticle Enhances Antibacterial Sonodynamic Therapy for Effective Eradication of Pseudomonas aeruginosa Biofilm

Xin,

Shen,

Huang

et al. 2024

BIOI

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Infections caused by Pseudomonas aeruginosa biofilm significantly endanger human health worldwide. Biofilms are closely associated with antibiotic resistance because biofilms significantly undermine the efficacy of antibiotics. A novel ultrasound-launched targeted nanoparticle was developed to universally destroy biofilm, target bacteria, deliver antibiotics, and efficiently kill bacteria via ultrasonic cavitation and antibacterial sonodynamic therapy. The nanoparticle consisted of poly (lactic-co-glycolic acid) loading ciprofloxacin and perfluoropentane with a bacteria-targeted antibody installed on the nanoparticle for binding to specific bacteria. The nanoparticle exhibited a sensitive response to ultrasound and the rapid liquid-gas phase transition of perfluoropentane resulted in a cavitation effect that destroyed the extracellular polymeric substances of the biofilm and allowed deep penetration of the antibiotics. In addition, ciprofloxacin induced additional reactive oxygen species production under ultrasound stimulation, leading to an enhanced bactericidal effect and potent anti-infective activity in vivo. This study presents an effective strategy to tackle the extracellular polymeric substance barriers for overcoming antibiotic resistance and removing a biofilm.

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Spectroscopic investigation on protein damage by ciprofloxacin under ultrasonic irradiation

Cited by 14 publications

References 37 publications

Metal–Organic Frameworks (MOF)-Assisted Sonodynamic Therapy in Anticancer Applications

Metal–Organic Frameworks (MOF)-Assisted Sonodynamic Therapy in Anticancer Applications

Organic Sonosensitizers for Sonodynamic Therapy: From Small Molecules and Nanoparticles toward Clinical Development

Ultrasound-Launched Targeted Nanoparticle Enhances Antibacterial Sonodynamic Therapy for Effective Eradication of Pseudomonas aeruginosa Biofilm

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