Spectroscopic Imaging of Compacted Pharmaceutical Tablets

Chan, K. L. Andrew; Elkhider, Noha; Kazarian, Sergei G.

doi:10.1205/cherd.05088

Cited by 42 publications

(32 citation statements)

References 9 publications

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“…The frequency variations that appear by the presence of different functional groups within the molecule can be explained by FTIR studies (Chan et al, 2005;Kazarian et al, 2005;Kazarian & Chan, 2006). The TCA powder analysis (Figure 5a) shows identical peaks to previously published work and confirms the presence of TCA (Mooranian et al, 2014g).…”

Section: Chemical Stability Studiessupporting

confidence: 82%

A comprehensive study of novel microcapsules incorporating gliclazide and a permeation enhancing bile acid: hypoglycemic effect in an animal model of Type-1 diabetes

et al. 2015

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Context: Gliclazide (G) is a commonly prescribed drug for Type 2 diabetes (T2D). In a recent study, we found that when G was combined with a primary bile acid, and gavaged to an animal model of Type 1 diabetes (T1D), it exerted a hypoglycemic effect. We hypothesized this to be due to metabolic activation of the primary bile acid into a secondary or a tertiary bile acid, which enhanced G solubility and absorption. The tertiary bile acid, taurocholic acid (TCA), has shown strong permeation-enhancing effects in vivo. Thus, we aimed to design, characterize, and test microcapsules incorporating G and TCA in an animal model of T1D. Methods: Microcapsules were prepared using the polymer sodium alginate (SA). G-SA microcapsules (control) and G-TCA-SA microcapsules (test) were extensively examined (in-vitro) at different pH and temperatures. The microcapsules were gavaged to diabetic rats, and blood glucose and G concentrations in serum were examined. Ex-vivo studies were also performed using a muscle cell line (C2C12), and cell viability and glucose intake post-treatment were examined. Results: G-TCA-SA microcapsules showed good stability, uniformity, and thermal and chemical excipient compatibilities. TCA did not change the size or the shape of the microcapsules, but it enhanced their mechanical resistance and reduced their swelling properties. G-TCA-SA enhanced the viability of C2C12 cells over 24 hours, and exerted a hypoglycemic effect in alloxan-induced type-1 diabetic rats. Conclusions: The incorporation of TCA into G-microcapsules resulted in functionally improved microcapsules with a positive effect on cell viability and glycemic control in Type-1 diabetic animals.

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Section: Chemical Stability Studiessupporting

confidence: 82%

A comprehensive study of novel microcapsules incorporating gliclazide and a permeation enhancing bile acid: hypoglycemic effect in an animal model of Type-1 diabetes

et al. 2015

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“…The lack of sample preparation is a useful property of the ATR methodology as transmission mode requires careful microtoming of the sample into thicknesses of less than 10-20 mm, while ATR-FTIR imaging allows for the study of many aspects of the tablets. The most important property of imaging is its ability to assess the spatial distribution of different components within the sample [66][67][68]. By taking several images of a sample, changes in the distribution can be studied; for example, when undergoing compaction, the positions of particles within the tablet rearrange, followed by the particles crumbling, and then the voids within the material collapse resulting in a harder denser material.…”

Section: Imaging Of Compacted Pharmaceutical Tabletsmentioning

confidence: 99%

“…A custom designed compaction cell has been developed to work in conjunction with a diamond ATR crystal and Golden GateÔ accessory that allows for in situ compaction of the pharmaceutical powders into model tablets [68]. The operation of this cell is shown in Figure 10.7.…”

Section: Imaging Of Compacted Pharmaceutical Tabletsmentioning

confidence: 99%

“…In the diamond dissolution cell, as the formulation is compacted onto the diamond, leakage is very unlikely [66]; the swelling of polymers such as HPMC further helps to prevent this ingress [14]. For the ZnSe crystal, the sample can be formed in situ if the polymer has a low melting point, and this has been used to study the dissolution of PEG-based formulations [68]. A schematic diagram of the ZnSe dissolution cell can be seen in Figure 10.18.…”

Section: Flow-through Dissolution Studied With Ftir Imagingmentioning

confidence: 99%

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Applications of FTIR Spectroscopic Imaging in Pharmaceutical Science

Kazarian

Wray

2010

Raman, Infrared, and Near‐Infrared Chemical Imaging

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“…Classical least squares (CLS) (1) has been used for predicting the species concentrations in each pixel of images of pharmaceutical products of known composition, using NIR and Fourier transform infrared (FTIR) spectroscopy imaging [13,16,17]. Assuming a linear mixing scenario, each observed spectral vector (e.g., all the available spectral bounds in each pixel) is modelled as…”

Section: Introductionmentioning

confidence: 99%