Spectroscopic, EPR, X-ray structural, and DFT studies of the complex compound of N4-donor ligand with copper(II)

Yılmaz, İsmail; Açar, Nursel; Coles, Simon J.; Şengül, Abdurrahman

doi:10.1016/j.molstruc.2020.128204

Cited by 4 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The synthesis and purification details of the ligand have been previously reported (14,21), and the characterization data are identical with the literature data (14). ESI-MS: m/z 411.1…”

Section: Synthesizing the Ligand 66'-bis(nh-benzimidazol-2-yl)-22'-bi...mentioning

confidence: 64%

See 1 more Smart Citation

Differential Cytotoxic Activity of a New Cationic Pd(II) Coordination Compound with N4-Tetradentate Hybrid Ligand in Cancer Cell Lines

Genel¹,

Selvi²,

Yılmaz³

et al. 2022

experimed

View full text Add to dashboard Cite

Objective: Successful cancer treatment still requires the discovery of novel compounds that hold promise for chemotherapeutics. The objective of this study was to examine the effectiveness of a newly synthesized cationic palladium(II) coordination compound that functions via several pathways to provide an efficient therapeutic option for various cancer cells. Materials and Methods:A new cationic palladium(II) coordination compound, [Pd(L)]Cl 2 •H 2 O, denoted as Complex 1, where the ligand L is the compound 6,6'-bis(NH-benzimidazol-2-yl)-2,2'-bipyridine), was synthesized and characterized by the attenuated total reflectance (ATR) -fourier-transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance ( 1 H NMR), electrospray ionization mass spectrometry (ESI-MS), and carbon-hydrogen-nitrogen (CHN) analyses. The density functional theory (DFT) calculations show the coordination sphere around the metal center in Complex 1 to be made up of tertiary N atoms of the pyridine (py) and benzimidazole (bim) rings completing the square-planar geometry with significant distortion. The anti-growth/cytotoxic activity of the complex was determined using the sulforhodamine B (SRB) and adenosine triphosphate (ATP) viability assays for 24 and 48 h in vitro. The study evaluates the determinations for annexin V-propidium iodide (PI) positivity, mitochondrial membrane potential loss, Bcl-2 protein inactivation, and deoxyribonucleic acid (DNA) damage to investigate the cell death mode and its partial mechanism.Results: Complex 1 caused cytotoxicity in a dose-dependent manner in all the cell lines used, with IC 50 values ranging from 2.6-8.8 μM for 48 h. Among the cancer models, colon and breast cancer cell lines underwent cell death by well-described apoptosis through the intrinsic pathway involving the mitochondria. However, the other cell lines did not show such a cell death modality. This implies that differential cell death modes operate based on the cancer type. Conclusion:For the treatment of breast and colon cancers, the complex 1 appears to be a unique, promising complex. Therefore, complex 1 deserves further attention for proof of concept in animal models.

show abstract

“…The synthesis and purification details of the ligand have been previously reported (14,21), and the characterization data are identical with the literature data (14). ESI-MS: m/z 411.1…”

Section: Synthesizing the Ligand 66'-bis(nh-benzimidazol-2-yl)-22'-bi...mentioning

confidence: 64%

“…The N 4 -donor tetradentate hybrid ligand (L) was synthesized as reported previously (21), with the specifics of the synthesis and characterization of the ligand having been recently detailed (24). The characterization data for L are identical to those of the reported data (24).…”

Section: Synthesis and Characterizationmentioning

confidence: 88%