Spectroscopic distinguishability, forced degradation kinetics and lc-ms/ms degradation product characterizations involving 5-fluorouracil and similar or affiliated compounds in relation to environmental concerns
Abstract:5-Fluorouracil (5-FU) is a commonly used antiviral and anticancer drug. 5-FU is believed to exist in various tautomeric forms, which are believed to contribute to 5-FU's cytotoxicity. In order to understand the activity of 5-FU in biological and environmental settings, a combined theoretical and experimental approach was used to determine the predominant tautomer in aqueous environments. Spectral characterization of 5-FU will enable development of improved analytical methods for 5-FU. The structures of the 6 m… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.