Spectroscopic detection of biological NO with a quantum cascade laser

Menzel, Laird W.; Kosterev, Anatoliy A.; Curl, R. F.; Tittel, Frank K.; Gmachl, Claire F.; Capasso, F.; Sivco, D. L.; Baillargeon, J. N.; Hutchinson, Albert L.; Cho, A. Y.; Urban, W.

doi:10.1007/s003400100562

Cited by 126 publications

(74 citation statements)

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“…Photoacoustic spectroscopy (PAS) is a well-established technique for measurements of trace gases at atmospheric pressure in various applications, such as environmental monitoring [1], industrial process control [2] or medical diagnostic by breath analysis [3]. PAS is a calorimetric method in which the optical energy absorbed in a gas sample is directly measured through the thermal transfer induced in the medium.…”

Section: Introductionmentioning

confidence: 99%

Sub-ppm multi-gas photoacoustic sensor

Besson

Schilt

Thévenaz

2006

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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A photoacoustic multi-gas sensor using tuneable laser diodes in the near-infrared region is reported. An optimized resonant configuration based on an acoustic longitudinal mode is described. Automatic tracking of the acoustic resonance frequency using a piezo-electric transducer and a servo electronics is demonstrated. Water vapour, methane and hydrogen chloride have been measured at sub-ppm level in different buffer gas mixtures. The importance of the system calibration in presence of several diluting gases is discussed. Finally, trace gas measurements have been assessed and detection limits (signal-to-noise ratio = 3) of 80 ppb at 1651.0 nm for CH 4 , 24 ppb at 1368.6 nm for H 2 O and 30 ppb at 1737.9 for HCl have been demonstrated.

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Section: Introductionmentioning

confidence: 99%

Sub-ppm multi-gas photoacoustic sensor

Besson

Schilt

Thévenaz

2006

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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“…Soon after the first appearance of these lasers, gas monitoring applications using various detection schemes were reported (Sharpe et al, 1998;Kosterev et al, 2008). Quantum-cascade lasers were used to detect ammonia and water vapor at 8.5 µm (Paldus et al, 1999), NO at 5.2 µm (Menzel et al, 2001), 12 CH 4 , 13 CH 4 and N 2 O isotopomers at 8.1 µm (Gagliardi et al, 2002), trace gases (CH 4 , N 2 O, H 2 O) in laboratory air at 7.9 µm (Kosterev & Tittel, 2002), carbon dioxide, methanol and ammonia at 10.1/10.3 µm (Hofstetter et al, 2001), CH 4 and NO at 7.9 µm and 5.3 µm (Grossel et al, 2006;Grossel et al, 2007) and simultaneously CO and SO 2 at 4.56 µm and 7.38 µm (Liu et al, 2011). In contrast to semiconductor (diode) lasers, quantum-cascade lasers are unipolar light sources based on only one type of carrier, usually electrons, making intraband transitions between confined energy levels within the conduction band.…”

Section: Discussionmentioning

confidence: 99%

CO2 Laser Photoacoustic Spectroscopy: I. Principles

Dumitraş¹,

Bratu²,

Popa³

2012

CO2 Laser - Optimisation and Application

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“…In this configuration, the light is repeatedly reflected by the mirrors, however, the reflection points are spatially sepa− rated [44]. The free−spectral range (FSR) of an off−axis ca− vity can be n times less than the FSR of an on−axis aligned cavity, where n is the number of the return trips for which a laser beam returns exactly to its entrance point.…”

Section: Cavity Ring-down Spectroscopymentioning

confidence: 99%

Ultrasensitive laser spectroscopy for breath analysis

Wojtas

Bielecki

Stacewicz

et al. 2012

Opto-Electronics Review

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At present there are many reasons for seeking new methods and technologies that aim to develop new and more perfect sensors for different chemical compounds. However, the main reasons are safety ensuring and health care. In the paper, recent advances in the human breath analysis by the use of different techniques are presented. We have selected non-invasive ones ensuring detection of pathogenic changes at a molecular level. The presence of certain molecules in the human breath is used as an indicator of a specific disease. Thus, the analysis of the human breath is very useful for health monitoring. We have shown some examples of diseases’ biomarkers and various methods capable of detecting them. Described methods have been divided into non-optical and optical methods. The former ones are the following: gas chromatography, flame ionization detection, mass spectrometry, ion mobility spectrometry, proton transfer reaction mass spectrometry, selected ion flow tube mass spectrometry. In recent twenty years, the optical methods have become more popular, especially the laser techniques. They have a great potential for detection and monitoring of the components in the gas phase. These methods are characterized by high sensitivity and good selectivity. The spectroscopic sensors provide the opportunity to detect specific gases and to measure their concentration either in a sampling place or a remote one. Multipass spectroscopy, cavity ring-down spectroscopy, and photo-acoustic spectroscopy were characterised in the paper as well.

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Spectroscopic detection of biological NO with a quantum cascade laser

Cited by 126 publications

References 0 publications

Sub-ppm multi-gas photoacoustic sensor

Sub-ppm multi-gas photoacoustic sensor

CO2 Laser Photoacoustic Spectroscopy: I. Principles

Ultrasensitive laser spectroscopy for breath analysis

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