Spectroscopic characterization of cardiovascular tissue

Clarke, Richard H.; Isner, Jeffrey M.; Gauthier, Thomas; Nakagawa, Kouichi; Cerio, Frank; Hanlon, Eugene B.; Gaffney, Edward J.; Rouse, Elizabeth D.; Dejesus, S. R.

doi:10.1002/lsm.1900080110

Cited by 62 publications

(20 citation statements)

References 17 publications

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“…The different physical properties of these fluids may result in different photoproducts upon ablation and different absorption of fluorescence emission in the case of calcified lesions. The broad-banded spectra of calcified material in sa- line and blood also differed significantly from the corresponding spectrum in air dominated by calcium I and II lines [15,16,23,26]. This transition can be attributed to plasma formation in air which is not present in a fluid environment [23,26].…”

Section: Discussion Spectral Analysis In Vitromentioning

confidence: 70%

Single-laser approach for fluorescence guidance of excimer laser angioplasty at 308 nm: Evaluation in vitro and during coronary angioplasty

et al. 1997

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Section: Discussion Spectral Analysis In Vitromentioning

confidence: 70%

Single-laser approach for fluorescence guidance of excimer laser angioplasty at 308 nm: Evaluation in vitro and during coronary angioplasty

et al. 1997

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“…However, although the ability of LIF to differentiate between normal and atherosclerotic arterial wall was reported [2,3,14,15], a high classification accuracy has not been found for all subtypes of plaque. Specifically, heavily calcified atherosclerotic specimens have occasionally displayed normal fluorescence spectral patterns [16], although controversial results were also reported [17].…”

Section: Introductionmentioning

confidence: 80%

Spectroscopic characterisation of carotid atherosclerotic plaque by laser induced fluorescence

et al. 2000

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“…Furthermore, plasma detection enhances the classification accuracy of fluorescence spectroscopy for atherosclerotic tissue. Plasma emission has been described during excimer [13,17] and dye [9,10] laser ablation of calcified atherosclerotic plaque. In these studies using ultraviolet or visible wavelengths, respectively, ablative laser fluences were also required for plasma photoemission.…”

Section: Discussionmentioning

confidence: 99%

Detection of calcified atherosclerotic plaque by laser‐induced plasma emission

et al. 1992

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The use of fluorescence spectroscopy to discriminate atherosclerotic from normal tissue is limited by a lower sensitivity for calcified than noncalcified atherosclerotic plaque (65% vs. 93%, respectively). To evaluate plasma emission as a means to detect calcified plaque, 325 normal and atherosclerotic cadaveric aortic sites were irradiated through a 100-micron silica fiber in blood by a pulsed holmium laser (lambda = 2.1 microns, fluence = 4 J/mm2). A photodiode positioned near the proximal end of the fiber detected plasma emission during a laser pulse. Plasma emission was detected at 0% (0/110) of normal, 0% (0/107) of noncalcified atherosclerotic tissue, and 91% (98/108) of calcified atherosclerotic sites. Spectroscopic analysis confirmed the presence of calcium lines in the plasma emission from calcified atherosclerotic plaque. Although ablative fluences (greater than 3 J/mm2) were required for plasma generation, a single laser pulse ablated only to a depth of 67 +/- 16 microns in normal tissue. In an additional 10 calcified atherosclerotic sites, laser ablation was continued as long as plasma emission was detected. In all cases, plaque ablation was terminated before arterial perforation. Furthermore, the adjunctive use of plasma detection improved the accuracy of fluorescence spectroscopic classification of normal and atherosclerotic tissue. In conclusion, plasma detection has a high sensitivity (91%) and specificity (100%) for calcified atherosclerotic plaque and may be a useful adjunct for laser angioplasty guidance. Furthermore, plasma detection can be implemented both simply and inexpensively.

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Spectroscopic characterization of cardiovascular tissue

Cited by 62 publications

References 17 publications

Single-laser approach for fluorescence guidance of excimer laser angioplasty at 308 nm: Evaluation in vitro and during coronary angioplasty

Single-laser approach for fluorescence guidance of excimer laser angioplasty at 308 nm: Evaluation in vitro and during coronary angioplasty

Spectroscopic characterisation of carotid atherosclerotic plaque by laser induced fluorescence

Detection of calcified atherosclerotic plaque by laser‐induced plasma emission

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