Spectroscopic characterization and biological studies in vitro of a new silver complex with furosemide: Prospective of application as an antimicrobial agent

Lustri, Wilton R.; Lazarini, Silmara C.; Lustri, Bruna Cardinali; Corbi, Pedro P.; Silva, Maria Aline C.; Resende, Flávia Aparecida; Aquino, Renata; Amaral, André Capaldo; Filho, Oswaldo Treu; Massabni, Antônio Carlos; Barud, Hernane da Silva

doi:10.1016/j.molstruc.2016.12.056

Cited by 18 publications

(14 citation statements)

References 41 publications

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“…The results obtained in this work demonstrated that the [Ag2(C4H4O4)] complex showed significant growth inhibition activity of the tested bacterial species, when compared with other studies that report the inhibitory activity of bacterial growth by Ag(I) complexes with several ligands, as Ag(I) with furosemide (MIC = 0.39 mmol L -1 for gram-positive bacteria strains) 32 , sulfathiazole (MIC 3.45 mmol L -1 for gram-negative bacteria and 6.90 mmol L -1 for Gram-positive bacteria strains) and sulfamethoxazole (MIC = 1.74 mmol L -1 for gram-negative bacteria and 13.9 mmol L -1 for gram-positive bacteria) 39 . The results demonstrate the potential for using the [Ag2(C4H4O4)] complex as an antibacterial drug in the future.…”

Section: Minimum Inhibitory Concentration (Mic)supporting

confidence: 55%

“…Determination of the minimum inhibitory concentration (MIC) of the free ligand and [Ag2(C4H4O4)] was performed using different reference bacterial strains, S. aureus ATCC 25923, B. cereus ATCC 14579, E. coli ATCC 25922 and P. aeruginosa ATCC 27853, as described in CLSI 2016 31,32 . The bacterial strains were inoculated in tubes containing 10.0 mL of brain heart infusion (BHI KASVI) and incubated for 18 h at 35-37 °C.…”

Section: Determination Of the Minimal Inhibitory Concentration (Mic)mentioning

confidence: 99%

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Chemical, spectroscopic characterization, molecular modeling and antibacterial activity assays of a silver (I) complex with succinic acid

et al. 2021

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A silver(I) complex with succinic acid in the form of succinate is presented. Chemical characterization confirms the molecular composition Ag2C4H4O4 for the complex. Infrared spectra suggest a bidentate coordination of both carboxylate groups of succinates to the two Ag(I) ions. Density functional theory (DFT) studies were used in the structures of succinic acid and Ag(I) succinate complex with coordination formula [Ag2(C4H4O4)] in order to optimize them to their minimum energy. The studies confirmed that each carboxylate group of the succinate anion is coordinated to one silver atom by the two oxygen in a bidentate mode and the bond lengths O···Ag theoretically determined range from 2.325 to 2.338 Å. The complex [Ag2(C4H4O4)] showed in vitro antibacterial activity against the bacterial strains of Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa complex. Anti-Mycobacterium tuberculosis analyses were also performed and the [Ag2(C4H4O4)] complex was shown to be active over M. tuberculosis H37Rv strain with MIC90 of 23.94 μg mL-1 while succinic acid itself showed a value higher than 25.00 μg mL-1.

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Section: Minimum Inhibitory Concentration (Mic)supporting

confidence: 55%

Section: Determination Of the Minimal Inhibitory Concentration (Mic)mentioning

confidence: 99%

Chemical, spectroscopic characterization, molecular modeling and antibacterial activity assays of a silver (I) complex with succinic acid

et al. 2021

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“…A literature reported procedure with minor modifications was used to synthesise Ag (I) complex of FSE (Ag-FSE) [12]. In brief, a solution of AgNO 3 (0.362 g, 2.13 mmol) in water (2 ml) was added dropwise to a methanolic solution (20 ml) of FSE (0.704 g, 2.13 mmol) and KOH (0.119 g, 2.13 mmol) under stirring.…”

Section: Synthesis Of Ag-fse (Fig 1)mentioning

confidence: 99%

“…Recently, researchers have synthesised an Ag complex of furosemide (FSE), a diuretic and antihypertensive drug, and evaluated it for antimicrobial activity. The studies revealed that FSE-Ag complex (Ag-FSE) could be a good antibacterial drug for future use in medicine [12]. However, the synthesised Ag-FSE is highly insoluble in water and most of the organic solvents.…”

Section: Introductionmentioning

confidence: 99%

FSE–Ag complex NS: preparation and evaluation of antibacterial activity

Kalhapure

Bolla

Domı́nguez

et al. 2018

IET nanobiotechnol.

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Silver (Ag) complexes of drugs and their nanosystems have great potential as antibacterials. Recently, an Ag complex of furosemide (Ag-FSE) has shown to be a promising antimicrobial. However, poor solubility of Ag-FSE could hamper its introduction into clinics. Therefore, the authors developed a nanosuspension of Ag-FSE (Ag-FSE_NS) for its solubility and antibacterial activity enhancement. The aim of this study was to introduce a novel nanoantibiotic with enhanced antibacterial efficacy. Ag-FSE_NS was prepared by precipitation-ultrasonication technique. Size, polydispersity index (PI) and zeta potential (ZP) of prepared Ag-FSE_NS were measured by dynamic light scattering, whereas surface morphology was determined using scanning electron microscopy (SEM). antibacterial activity was evaluated against, and using broth microdilution method. Size, PI and ZP of optimised Ag-FSE_NS1 were 191.2 ± 19.34 nm, 0.465 ± 0.059 and -55.7 ± 8.18 mV, respectively. SEM revealed that Ag-FSE_NS1 particles were rod or needle-like with smooth surfaces. Saturation solubility of Ag-FSE in NS increased eight-fold than pure Ag-FSE. Ag-FSE_NS1 exhibited two-fold and eight-fold enhancements in activity against and, respectively. The results obtained showed that developed Ag-FSE_NS1 holds a promise as a topical antibacterial.

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“…Silver, copper, zinc and iron are metals which form complexes with furosemide for different purposes. For example, silver‐furosemide complexes showed anti‐bacterial activity against Gram‐positive such as Staphylococcus aureus and Gram negative such as Escherichia coli and Pseudomanas aeruginosa . The complexation of furosemide with copper(II) and Fe(III) chloride were also used for the determination of furosemide content …”

Section: Introductionmentioning

confidence: 99%

Synthesis, Structures and Various Biological Applications of New Zn(II) Complexes Having Different Coordination Modes Controlled by the Drug Furosemide in Presence of Bioactive Nitrogen Based Ligands

Raymoni

Ali

2018

Applied Organom Chemis

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Novel Zn(II) complexes with the general formula: [Zn(furo) 2 (L) n ], n = 1 or 2, (furo = furosemide = (4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid) were prepared. The complexes [Zn(furo) 2 (MeOH) 2 ] (1; MeOH = methanol), [Zn(furo) 2 (2-ampy) 2 ] (2; 2-ampy = 2-aminopyridine), [Zn(furo) 2 (2-ammepy) 2 ] (3; 2-ammepy = 2-aminomethylpyridine), [Zn(furo) 2 (H 2 O)(2,2-bipy)] (4; 2,2′bipy = 2,2′-bipyridine), [Zn(furo) 2 (H 2 O)(4,4′-bipy)] (5; 4,4′-bipy = 4,4′bipyridine), [Zn(furo) 2 (1,10-phen)] (6; 1,10-phen = 1,10-phenanthroline),[Zn(furo) 2 (2,9-dmp)] (7; 2,9-dmp = 2,9-dimethyl-1,10-phenanthroline), and [Zn (furo) 2 (quin) 2 ] (8; quin = quinoline) were synthesized and characterized using different techniques such as IR, UV-Vis, 1 H NMR, 13 C NMR, LC/MS and others. The crystal structure of complex (4) was determined using singlecrystal X-ray diffraction.The anti-bacterial activity of complexes (1-8) was tested using agar diffusion method against three gram-positive (Staphylococcus aureus, Bacillus subtilis and Staphylococcus epidermidis) and three gram-negative bacteria (Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa). The obtained results showed different Inhibition Zone Diameters (IZD) with various anti-bacterial activities against the selected gram-positive and gram-negative bacteria. In addition, the rate of bis-(4-nitrophenyl) phosphate hydrolysis was measured at different temperatures, different pH values and different concentrations. The rates for the eight complexes were in the following order: complex 4 > 2 > 5 > 8 > 7 > 6 > 3 > 1. KEYWORDS anti-bacterial activity, bioactive nitrogen based ligands, bis-(4-nitrophenyl) phosphate, furosemide, zinc(II) complexes

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Spectroscopic characterization and biological studies in vitro of a new silver complex with furosemide: Prospective of application as an antimicrobial agent

Cited by 18 publications

References 41 publications

Chemical, spectroscopic characterization, molecular modeling and antibacterial activity assays of a silver (I) complex with succinic acid

Chemical, spectroscopic characterization, molecular modeling and antibacterial activity assays of a silver (I) complex with succinic acid

FSE–Ag complex NS: preparation and evaluation of antibacterial activity

Synthesis, Structures and Various Biological Applications of New Zn(II) Complexes Having Different Coordination Modes Controlled by the Drug Furosemide in Presence of Bioactive Nitrogen Based Ligands

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