Spectroscopic approach of the interaction study of ceftriaxone and human serum albumin

Teir, Musa M. Abu; Ghithan, Jafar; Abu-Taha, M. I.; Darwish, S.; M, Abu-hadid M.

doi:10.5897/jbsb2013.0045

Cited by 31 publications

(15 citation statements)

References 41 publications

(43 reference statements)

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“…At the same time, the hydrophobic cavity in site II is smaller than that in site I [ 40 ]. It has been shown in the literature that, in contrast to LV, which binds equally strongly in subdomains IIA and IIIA [ 41 ], CT, being a rather large molecule, binds much weaker in site II than in site I [ 42 , 43 ].…”

Section: Resultsmentioning

confidence: 99%

The Formation of β-Cyclodextrin Complexes with Levofloxacin and Ceftriaxone as an Approach to the Regulation of Drugs’ Pharmacokinetic

et al. 2023

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— The study has been devoted to the complexation of hydroxypropyl-β-cyclodextrin (HPCD) with antibacterial drugs, namely, ceftriaxone (CT) and levofloxacin (LV), which are used to treat respiratory diseases, including bacterial infections of the respiratory tract. FTIR and NMR spectroscopic investigations have shown that the LV–HPCD complex is formed mainly due to the inclusion of the aromatic fragment of LV into the HPCD cavity; while the CT–HPCD complex is realized on the HPCD surface. Being a more hydrophobic molecule, LV forms ten times stronger complexes with HPCD than does CT: K disLV-HPCD ~ 10 –3 M, while K disCT-HPCD ~10 –2 M at pH 7.4. It has been shown that, for singly charged forms of the drugs, the complexes are two times more stable. Fluorescence spectroscopy has been employed to study the thermodynamic parameters for the interaction of dosage forms with human serum albumin. Negative values of Δ H and Δ S of the reaction have indicated both hydrogen bonding and van der Waals interactions during the complexation of both drugs with human serum albumin. It has been found that the protein is ~4 times more strongly bound to LV at 37°C as compared with CT. The data obtained will make it possible to improve the characteristics of the studied drugs and bring the methods of treating severe forms of respiratory diseases to a new level.

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Section: Resultsmentioning

confidence: 99%

The Formation of β-Cyclodextrin Complexes with Levofloxacin and Ceftriaxone as an Approach to the Regulation of Drugs’ Pharmacokinetic

et al. 2023

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“…Absorption spectroscopy methods such as ultraviolet (UV) [ 14 , 86 , 87 , 88 , 89 , 90 ], infrared spectroscopy [ 14 , 88 , 90 , 91 , 92 ], spectrofluorimetry [ 14 , 93 ], microbiological methods [ 14 , 94 , 95 ], and capillary zone electrophoresis [ 96 ] have also been used for the analysis of ceftriaxone. When used as an identification technique, UV has limited selectivity because multiple compounds may have the same or similar spectra.…”

Section: Methods Used To Analyze Antibioticsmentioning

confidence: 99%

A Review of Methods for Removal of Ceftriaxone from Wastewater

Karungamye

Rugaika

Mtei

et al. 2022

JoX

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The presence of pharmaceuticals in surface water and wastewater poses a threat to public health and has significant effects on the ecosystem. Since most wastewater treatment plants are ineffective at removing molecules efficiently, some pharmaceuticals enter aquatic ecosystems, thus creating issues such as antibiotic resistance and toxicity. This review summarizes the methods used for the removal of ceftriaxone antibiotics from aquatic environments. Ceftriaxone is one of the most commonly prescribed antibiotics in many countries, including Tanzania. Ceftriaxone has been reported to be less or not degraded in traditional wastewater treatment of domestic sewage. This has piqued the interest of researchers in the monitoring and removal of ceftriaxone from wastewater. Its removal from aqueous systems has been studied using a variety of methods which include physical, biological, and chemical processes. As a result, information about ceftriaxone has been gathered from many sources with the searched themes being ceftriaxone in wastewater, ceftriaxone analysis, and ceftriaxone removal or degradation. The methods studied have been highlighted and the opportunities for future research have been described.

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“…Cft-Na (Scheme 2, Supporting Information), a third-generation semisynthetic cephalosporin antibiotic, has broad-spectrum activity against Gram-positive and Gram-negative bacteria with low toxicity and long halflife. 12,13 Ceftriaxone is used for treatment of various infections caused by specific bacteria, such as blood poisoning meningitis and gonorrhea, 14 and infections caused by Neisseria gonorrhoeae and Salmonella typhi. 15 It is often used for the treatment of community-acquired or mild-to-moderate healthcare-associated pneumonia and is also a choice for treatment of bacterial meningitis.…”

Section: Introductionmentioning

confidence: 99%

“…Also, to cope with the drug solubility/permeability problem, the drug–bile salt combination may be helpful, so by extending our previous studies , with such systems herein, we have intended to study the interactional behavior of drug–bile salt system by taking ceftriaxone sodium (Cft-Na) as a model drug. Cft-Na (Scheme 2, Supporting Information), a third-generation semisynthetic cephalosporin antibiotic, has broad-spectrum activity against Gram-positive and Gram-negative bacteria with low toxicity and long half-life. , Ceftriaxone is used for treatment of various infections caused by specific bacteria, such as blood poisoning meningitis and gonorrhea, and infections caused by Neisseria gonorrhoeae and Salmonella typhi . It is often used for the treatment of community-acquired or mild-to-moderate healthcare-associated pneumonia and is also a choice for treatment of bacterial meningitis .…”

Section: Introductionmentioning

confidence: 99%

Interactional Behavior of Sodium Cholate and Sodium Deoxycholate in the Presence of Ceftriaxone Sodium: Volumetric, Compressibility, Viscometric, and Proton Nuclear Magnetic Resonance Studies

Singh

Chauhan

2020

J. Chem. Eng. Data

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Interactional behavior of bile salts, namely, sodium cholate (NaC) and sodium deoxycholate (NaDC), in the presence of an antibiotic drug, ceftriaxone sodium (Cft-Na), at different temperatures has been analyzed through volumetric, compressibility, viscometric, and proton nuclear magnetic resonance ( 1 H-NMR) studies. The volumetric and compressibility parameters have been calculated with the help of measured density (ρ) and speed of sound (u). Also, the knowledge on intermolecular interactions present in a ternary system consisting of bile salts in aqueous solution of drug has been procured from viscometric measurements. The variation in strength of the present intermolecular interactions in the system with temperature and concentration has been analyzed by carrying out the experiments at different temperatures, i.e., 293.15, 298.15, 303.15, 308.15, and 313.15 K, and drug concentrations, i.e., 0.005, 0.010, and 0.050 mol•kg −1 . The results have been interpreted by considering the cosphere overlap model, which confirm the presence of hydrophobic and hydrophilic interactions in the system. Also, the information obtained from density, speed of sound, and viscometric studies has been strengthened by analyzing the 1 H-NMR spectra. The study may be helpful in utilization of bile salts in pharmaceutical industries as a penetration enhancer.

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Spectroscopic approach of the interaction study of ceftriaxone and human serum albumin

Cited by 31 publications

References 41 publications

The Formation of β-Cyclodextrin Complexes with Levofloxacin and Ceftriaxone as an Approach to the Regulation of Drugs’ Pharmacokinetic

The Formation of β-Cyclodextrin Complexes with Levofloxacin and Ceftriaxone as an Approach to the Regulation of Drugs’ Pharmacokinetic

A Review of Methods for Removal of Ceftriaxone from Wastewater

Interactional Behavior of Sodium Cholate and Sodium Deoxycholate in the Presence of Ceftriaxone Sodium: Volumetric, Compressibility, Viscometric, and Proton Nuclear Magnetic Resonance Studies

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