Spectroscopic and calorimetric studies of interactions between mitoxantrone and cucurbituril Q7 in aqueous solutions

A simple single jar “on–off fluorescence” designed system for the determination of mitoxantrone using an eosin Y dye in raw powder, vial, and human biofluids

“… 1 MTX attacks DNA strands in the human cell, thus obstructing its synthesis and preventing its repair process by disrupting the transcription and translation pathways in the damaged cell. 2 Due to its therapeutic importance, MTX was accurately determined in manufactured forms and biofluids. The recommended starting dose of mitoxantrone used as a single agent is 12–14 mg m −2 of body surface area, given as a single intravenous dose, which may be repeated at 21 day intervals.…”

Synthesis of an AIEgen functionalized cucurbit[7]uril for subcellular bioimaging and synergistic photodynamic therapy and supramolecular chemotherapy

“…AIECB [7] may spontaneously form nanoaggregates in an aqueous environment due to its amphiphilicity. Additionally, as CB [7]'s cavity was unoccupied, drug molecules such as oxaliplatin and banoxantrone (AQ4N) 16,25 can be loaded through host-guest recognition of CB [7], to realize imagingguided synergistic photodynamic-chemo therapy (Scheme 1). Scheme 1.…”

Host–Guest Complexation of Cucurbit[7]Uril and Cucurbit[8]Uril with the Antineoplastic and Multiple Sclerosis Agent Mitoxantrone (Novantrone)

“…In the smaller cavity of CB [7], only the aliphatic chains of the MX molecule undergo encapsulation, while the dihydroxyanthracenedione fragment of the bound drug remains outside the cavity of the macrocycle. 20 The abovementioned experimental studies indicate that MX guest molecules can be encapsulated in different ways in the three-dimensional cage by CB [7] and CB [8] ligands to form molecular complexes with varying stability and different ratios of guest-to-host molecules. The underlying thermodynamic parameters governing the host−guest complexation of CB [7] and CB [8] with MX still remain unknown.…”

“…The process of creating a supramolecular complex with a 1:2 stoichiometry (MX–2*CB[7]) has been found thermodynamically spontaneous. In the smaller cavity of CB[7], only the aliphatic chains of the MX molecule undergo encapsulation, while the dihydroxyanthracenedione fragment of the bound drug remains outside the cavity of the macrocycle …”