Spectrophotometric Methods for the Determination of Acediasulfone in Mixture with Cinchocaine

Mohammad, Mohammad Abdul‐Azim; Zawilla, Nagwan H.; El-Anwar, Fawzy; Aly, S. M. El-Moghazy

doi:10.1080/00032710601017870

Cited by 4 publications

(1 citation statement)

References 26 publications

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“…There are a few studies in the literature describing the determination of fluocortolone and its esters FCC and FCP using thin layer chromatography 122 [3] (TLC), high performance liquid chromatography [4][5] (HPLC), raman spectroscopy [6][7], and spectrophotometry [8]. Unlike fluocortolone, many studies including the use of spectrophotometry [2,9], fluorimetry [10], TLC [11], liquid chromatography-mass spectrometry [12], sequential injection chromatography [13], HPLC [2,[14][15][16], gas chromatography [17], chemometry [18] and electroanalytical methods [19][20][21] have been used for the determination of CIN. A HPLC method has been reported for the simultaneous determination of the three drugs [22].…”

Section: Introductionmentioning

confidence: 99%

Multivariate calibration method for Simultaneous estimation of Fluocortolone caproate, Fluocortolone pivalate and Cinchocaine HCl in suppository

Dönmez¹

2019

Studia UBB Chemia

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In this paper, the simultaneous quantitative assay of Fluocortolone caproate (FCC), Fluocortolone pivalate (FCP) and Cinchocaine HCl (CIN) in suppository has been reported as a simple alternative analytical method. A partial least squares (PLS-2) regression was used for resolution of the overlapped spectrophotometric signals from mixtures of the three drugs. A calibration set containing FCC, FCP and CIN was constructed by using 3 3 full factorial design in the concentration range of 4.5-8.5, 5-7 and 8-12 μg/mL, respectively. Absorption spectra were recorded in the range 240-350 nm. To check the quality of the proposed method, it was applied to the determination of these compounds in synthetic mixtures and pharmaceutical formulation, suppository. The PLS-2 method yielded recoveries ranging from 91 to 106%. The results compared well with those from the reported HPLC method.

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Section: Introductionmentioning

confidence: 99%

Multivariate calibration method for Simultaneous estimation of Fluocortolone caproate, Fluocortolone pivalate and Cinchocaine HCl in suppository

Dönmez¹

2019

Studia UBB Chemia

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Recent development in derivative ultraviolet/visible absorption spectrophotometry: 2004–2008

Rojas

Ojeda

2009

Analytica Chimica Acta

148

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Optimum HPLC Conditions for Determination of Dibucaine HCL, Fluocortolone Pivalate and Fluocortolone Caproate by Using Experimental Design

Koç

2018

CPA

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Introduction: This paper presents the development and validation of a novel, fast, sensitive and accurate high performance liquid chromatography (HPLC) method for the simultaneous quantitative determination of dibucaine HCl, fluocortolone pivalate and fluocortolone caproate in pharmaceutical preparations. Experiment: Development of the chromatographic method was based on an experimental design approach. A five-level-three-factor central composite design requiring 20 experiments in this optimization study was performed in order to evaluate the effects of three independent variances including mobile phase ratio, flow rate and amount of acid in the mobile phase. Conclusion: The optimum composition for mobile phase was found as a methanol:water:acetic acid mixture at 71.6 : 26.4 : 2 (v/v/v) ratio and optimum separation was acquired by isocratic elution with a flow rate of 1.3 mL/min. The analytes were detected using a UV detector at 240 nm. The developed method was validated in terms of linearity, precision, accuracy, limit of detection/quantitation and solution stability and successfully applied to the determination of dibucaine HCl, fluocortolone pivalate and fluocortolone caproate in pharmaceutical topical formulations such as suppositories and ointments.

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Spectrophotometric Methods for the Determination of Acediasulfone in Mixture with Cinchocaine

Cited by 4 publications

References 26 publications

Multivariate calibration method for Simultaneous estimation of Fluocortolone caproate, Fluocortolone pivalate and Cinchocaine HCl in suppository

Multivariate calibration method for Simultaneous estimation of Fluocortolone caproate, Fluocortolone pivalate and Cinchocaine HCl in suppository

Recent development in derivative ultraviolet/visible absorption spectrophotometry: 2004–2008

Optimum HPLC Conditions for Determination of Dibucaine HCL, Fluocortolone Pivalate and Fluocortolone Caproate by Using Experimental Design

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