Spectrophotometric Method For Simultaneous Estimation of Montelukast Sodium and Ebastine in Bulk and Their Combined Tablet Dosage Form

Patel, Nikita; Rana, Nikesh S.; Rajesh, K S; Patel, Parag R.; Limbachiya, Ujjaval; Pasha, T. Y.

doi:10.5530/ijper.48.2.12

Cited by 9 publications

(6 citation statements)

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“…In this study an attempt was made to develop a simple spectrophotometric method for the estimation of the present drug in dosage form. A similar method was reported by many authors (Gupta et al, 2009;Sevda et al, 2011;Patel et al, 2012;Gajjar et al, 2010;Prajapati et al, 2010;Shinde et al, 2015) for the estimation of rosuvastatin calcium by UV spectrophotometric method.…”

Section: Introductionsupporting

confidence: 59%

Determination of Rosuvastatin Calcium in bulk and Pharmaceutical dosage forms by using UV-Spectrophotometric method

Singh¹,

Gupta²,

Gautam³

2018

Asian J Pharm Pharmacol

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Objective: The aim of the present work was to develop a simple and sensitive UV spectrophotometric method for the estimation of rosuvastatin calcium in bulk and in pharmaceutical dosage form.Rosuvastatin Material and methods: calcium exhibits maximum absorbance at 244 nm with apparent molar absorptivity of 7.1862 × 10 L/mol.cm in 4 methanol as solvent. Beer's law was found to be obeyed in the concentration range 2-18 µg /ml for rosuvastatin calcium. Result and discussion: The results of the study demonstrated that the developed procedure was accurate, precise and economical. This method is further extended to pharmaceutical dosage form.In this method, no Conclusion: interference from any pharmaceutical additives and diluents were found. The validation of the analysis was done by statistically and recovery studies.

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Section: Introductionsupporting

confidence: 59%

Determination of Rosuvastatin Calcium in bulk and Pharmaceutical dosage forms by using UV-Spectrophotometric method

Singh¹,

Gupta²,

Gautam³

2018

Asian J Pharm Pharmacol

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“…The results of the proposed method are 4-200 times more sensitive than the reported chromatographic methods (4-7) for the simultaneous determination of DSL and MKT. Moreover, the proposed method is 20-90 and 10-90 times more sensitive than the reported spectrophotometric methods (8)(9)(10)(11)(12)(13) for DSL and MKT, respectively. This high sensitivity makes the proposed method superior to all methods reported in the literature.…”

Section: Methods Validationmentioning

confidence: 84%

“…Some analytical methods have been reported for the simultaneous determination of the two drugs in their co-formulated tablets, for example, HPLC (4-6), HPTLC (7) and spectrophotometry (8)(9)(10)(11)(12)(13). However, these methods (4-13) exhibit poor sensitivity, in addition to the elaborate treatments and expensive solvents needed for HPLC procedures (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of desloratadine and montelukast sodium using second‐derivative synchronous fluorescence spectrometry enhanced by an organized medium with applications to tablets and human plasma

et al. 2014

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A rapid, simple, and sensitive second-derivative synchronous fluorimetric method has been developed and validated for the simultaneous analysis of a binary mixture of desloratadine (DSL) and montelukast sodium (MKT) in their co-formulated tablets. The method is based on measurement of the synchronous fluorescence intensities of the two drugs in McIlvaine's buffer, pH 2.3, in the presence of carboxy methyl cellulose sodium (CMC) as a fluorescence enhancer at a constant wavelength difference (Δλ) of 160 nm. The presence of CMC enhanced the synchronous fluorescence intensity of DSL by 216% and that of MKT by 28%. A linear dependence of the concentration on the amplitude of the second derivative synchronous fluorescence spectra was achieved over the ranges of 0.10-2.00 and 0.20-2.00 µg/mL with limits of detection of 0.02 and 0.03, and limits of quantification of 0.05 and 0.10 µg/mL for DSL and MKT, respectively. The proposed method was successfully applied for the determination of the studied compounds in laboratory-prepared mixtures and tablets. The results were in good agreement with those obtained with the comparison method. The high sensitivity attained by the proposed method allowed the determination of MKT in spiked human plasma with average % recovery of 100.11 ± 2.44 (n = 3).

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“…3 Literature revels Montelukast sodium was determined form bulk, pharmaceutical formulations and plasma with various analytical methods including UV Spectroscopy, HPLC,LC-MS-MS,HPTLC alone and in combination with other drug molecules. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] , Levocetirizine was also determined alone or in combination with other drug molecules by derivative UV Spectroscopy, HPLC,LC-MS-MS,HPTLC methods [23][24][25][26][27][28][29] UV spectra of Montelukast sodium and Levocetirizine dihydrochloride shows that due to spectral overlap direct simple UV spectroscopic methods are not possible for simultaneous estimation of these two drugs [30][31] this issue can be addressed by application of chemometric tools like Arti cial Neural Network, Partial Least Squares s and Principal component Regression,.…”

Section: Introductionmentioning

confidence: 99%

A Chemometric Analysis of Montelukast Sodium And Levocetirizine Dihydrochloride In Pharmaceutical Formulations Using Artificial Neural Networks, Partial Least Squares, And Principal Component Regression Models

Jagdale,

Mitkari,

Sutar

2024

Preprint

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Present work describes applications and comparison of three models including Artificial intelligence-based ANN model and multivariate regression models namely PLS and PCR for simultaneous estimation of Montelukast sodium and Levocetirizine dihydrochloride in a tablet dosage form. Calibration and validation sets were prepared using standard solutions in a defined ratio as well as in random ratios. The UV absorption spectra of calibration set, and validation set were recorded in wavelength range of 200–400 nm using methanol as solvent. Three different models were constructed and validated using these sample sets. Three models were used to calculate the amount of drugs in the tablet formulation. Accuracy of the models was studied by performing recovery studies. Models were studied based on values obtained for root-mean-standard error for cross-validation, root-mean-standard error calibration, and correlation coefficients. All models showed lower values for the error terms and correlation values very close to one. Comparison of the three models shows that PLS, PCR and ANN models shows quite similar prediction ability, but ANN models need a larger number of samples to build a good model. These developed models were also compared with the reported HPLC method, and it was found that spectrophotometric based models are simple, rapid and gives better and faster prediction as compared to univariate models as well as costly, time consuming HPLC methods. Thus, these models may be used in the quality control department.

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Spectrophotometric Method For Simultaneous Estimation of Montelukast Sodium and Ebastine in Bulk and Their Combined Tablet Dosage Form

Cited by 9 publications

References 0 publications

Determination of Rosuvastatin Calcium in bulk and Pharmaceutical dosage forms by using UV-Spectrophotometric method

Determination of Rosuvastatin Calcium in bulk and Pharmaceutical dosage forms by using UV-Spectrophotometric method

Simultaneous determination of desloratadine and montelukast sodium using second‐derivative synchronous fluorescence spectrometry enhanced by an organized medium with applications to tablets and human plasma

A Chemometric Analysis of Montelukast Sodium And Levocetirizine Dihydrochloride In Pharmaceutical Formulations Using Artificial Neural Networks, Partial Least Squares, And Principal Component Regression Models

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