Eur J Chem volume 11, issue 4, P291-297 2020 DOI: 10.5155/eurjchem.11.4.291-297.2002
Hutaf Mustafa Baker, Hussam Ahmad Alsaoud, Hamzeh Mohamad Abdel-Halim

A simple, sensitive and reproducible method for the determination of ranitidine hydrochloride in pharmaceutical preparations was investigated. This spectrophotometric method was based on the formation of a deep red color product with ninhydrin in basic media and the absorbance measured at λmax = 480 nm. The reaction occurs at 45 °C with pH = 10 having a contact time of 38 minutes. Under the optimum conditions, Beer’s Law is obeyed in the concentration range of 8.98×103 - 9.90×104 µg/L. The coefficient of cor…


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