Spectrophotometric Method Development and Validation of Prazosin

Nikam, Pooja; Baokar, Shrikrishna; Undare, Santosh; Patil, Ravindra N.

doi:10.5958/2349-2988.2016.00001.2

Cited by 1 publication

(1 citation statement)

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“…1). From the literature survey some supporting information were referred in the present research work such as, validated specific HPLC method for determination of prazosin, terazosin and doxazosin in the presence of degradation products formed under ICH recommended stress conditions (Bakshi et al,, 2004), determination of terazosin by MBTH and BPB reagents using spectrophotometric technique (Ramachandra and Naidu, 2016), Spectrophotometry method for the determination of Terazosin in tablet formulation (Shrivastava and Dhakad, 2016), stability indicating RP-HPLC method for the simultaneous determination of Prazosin, terazosin, Doxazosin in pharmaceutical formulations (Shrivastava and Gupta, 2012), stability indicating HPTLC determination of Terazosin in tablet formulation (Shrivastava et al, 2013), Spectrophotometric method development and validation of prazosin (Nikam et al, 2016), a new validated spectrophotometric method for the estimation of rabeprazole sodium in tablet dosage form (Domatoti andKoppula, 2012) and Stress degradation studies on telmisartan and development of a validated method by UV spectrophotometry in bulk and pharmaceutical dosage forms (Patel et al, 2011). There are a few available literatures which explain the method development, validation and stability studies for estimation of Terazosin by UV-Spectrophotometric method.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of Stability Indicating Method for Terazosin in Bulk and Pharmaceutical Formulation by UV-Spectrophotometer

Prasad,

Satyabrata,

Pritish Kumar

2023

Intern. J. Zool. Invest.

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Terazosin hydrochloride is indicated in the symptomatic relief of benign prostatic hyperplasia and it is also used as an antihypertensive agent. A rapid, simple, specific, and economic UV-spectrophotometric method has been developed to determine the stability indicating method for terazosin using water as a solvent. The absorption spectrum of terazosin showed maximum absorbance at 250 nm and obeyed Beer's law in concentration range 1.5-9 µg/ml. Linear regression of absorbance on concentration gave the equation y=0.1103x+0.0101 with correlation coefficient 0.999. The method developed is validated for parameters like specificity, linearity, range, accuracy, precision, limit of detection (LOD), limit of quantitation (LOQ), robustness as per Q2A specifications of the ICH guidelines. The drug sample was exposed to acid, alkali, and oxidation by hydrogen peroxide, thermal and photolytic conditions to study the forced degradation of the drug. The obtained results proved that this method can be employed for the routine analysis of terazosin in bulk as well as in the commercial formulations.

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Section: Introductionmentioning

confidence: 99%