Spectrophotometric Determination of Valsartan using p-Chloranilic Acid as π-Acceptor in Pure and in Dosage Forms

Abstract

The aim of this work was to develop a simple, sensitive and extraction free spectrophotometric method for the quantitative estimation of valsartan in both pure and in pharmaceutical preparations. The developed method is based on the charge transfer complexation reaction between valsartan (VRT) as n-electron donor and pchloranilic acid (p-CA) as π-acceptor. VRT reacts with p-CA in methanol to produce a bright pink colored complex with a maximum absorption at 530 nm. Beer's law was obeyed in the concentration range of 5-50 µg/mL. The linear regression equation of the calibration graph is A = 0.0081+0.0092C with a regression coefficient (r) of 0.9976 (n = 7). The molar absorptivity is calculated to be 2.06 × 10 3 L mol -1 cm -1 and the Sandell sensitivity is 0.1025 μg cm -2 . The limits of detection (LOD) and quantitation (LOQ) values are calculated according to ICH guidelines. The method developed is successfully applied to the determination of VRT in dosage forms.

Malleable Electronic Structure of Chloranilic Acid and Its Species Determined by X-ray Charge Density Studies

“…Chloranilic acid also readily forms salts and cocrystals with alkali ,, and organic cations involving a proton transfer . These properties of chloranilic acid have been widely used in analytical procedures exemplified by visible spectrophotometric determination of various pharmaceuticals, such as valsartan (blocking the action of angiotensin and dilating blood vessels manifested by reduced blood pressure) . Determination of metals using complexation ability of chloranilic acid in adsorption stripping voltammetry for metal traces has been exploited: detection of uranium traces in nuclear reactor IEA-R1 pool water and for sensitive quantification Ge (IV) …”

“…[6] These properties of chloranilic acid have been widely used in analytical procedures exemplified by visible spectrophotometric determination of various pharmaceuticals, such as valsartan (blocking the action of angiotensin and dilating blood vessels manifested by reduced blood pressure). [34] Determination of metals using complexation ability of chloranilic acid in adsorption stripping voltammetry for metal traces has been exploited: detection of uranium traces in nuclear reactor IEA-R1 pool-water [35] and for sensitive quantification Ge (IV). [36] Chloranilic acid is a strong donor and acceptor of hydrogen bonds [6,37] and also possesses an unusual propensity for cycle stacking.…”

Advanced Amplitude Centering as an Invigorating Manipulation for Unified Wavelength Spectral Resolution of Ternary Mixtures

“…The components of interest were amlodipine (AML), valsartan (VAL) and hydrochlorothiazide (HCT). Several analytical techniques, including chromatography, spectrophotometry and electrochemistry, were reported for the analysis of each the components individually: AML [8][9][10][11][12] , VAL [13][14][15][16] and HCT [17][18][19] The binary mixture of AML and VAL was determined using spectrophotometric [20] and HPLC methods [21] while the mixture containing AML and HCT was determined using spectrophotometric method [22] and capillary electrophoresis [23] The binary mixture of VAL and HCT was determined using spectroscopic, TLC and HPLC methods [24].…”

Spectrophotometric Determination of Ranitidine-HCl in Pure Form and Pharmaceutical Formulations with Metol and potassium hexacyanoferrate (ΙΙΙ)

“…These methods include kinetic spectrophotometry [3,4], HPLC [5,6],HPTLC [7],Micellarliquichromatography[8], liquidchromatographymassspectrometry [9,10],liquidchr omatography[11],capillary electrophoresis [12], fluorimetry [13], flow injection analysis [14,15], voltammeter [16],potentiometer [17,18],palarography [19 ], hanging mercury drop electrode [20],FT-IR [21], AAS [22], argentimetric[23], titrimetry [24] and UVspectrophotometry [25].But such techniques are time consuming because extensive sample pretreatment, required expensive instrumentation and beyond the reach of small laboratories, particularly in under developed and developing countries.The aim of the present work is to study the chargetransfer complex reaction in developing simple, accurate, sensitive and reproducible assays to determinetionRanitidine-HCl in pure form and pharmaceutical formulation [26].…”