“…To accomplish the total synthesis of securinine, diene 20 was oxidized at the allylic position with chromium trioxide and 3,5-dimethylpyrazole at −20 °C to provide lactone 21 . Finally, allylic bromination of 21 with NBS and AIBN, followed by removal of the protecting group with TFA and subsequent cyclization of the resulting amino bromide with potassium carbonate furnished (−)-securinine 1 , mp 142−143 °C ( n -hexane) (lit . mp 139−141 °C; lit …”