Spectrophotometric Determination of Raloxifene Hydrochloride in Pharmaceutical Formulations

Abstract

Three new simple, sensitive, rapid and economical spectrophotometric Methods (A, B and C) have been developed for the determination of Raloxifene Hydrochloride in pharmaceutical bulk and tablet dosage form. Method A is based on the formation of yellow colored chromogen with 0.1N Sodium hydroxide exhibiting maximum absorbance against the corresponding reagent blank. The method B is based on the reaction of Raloxifene with Ferric chloride and 1, 10-phenanthroline to form blood red colored chromogen. The method C is based on the formation of blood red colored chromogen with Ferric chloride and 2, 2' bipyridyl. The absorbencies of the chromogens were measured at their respective wavelength of maximum absorbance against the corresponding reagent blank. The proposed methods have been successfully applied to the analysis of the bulk drug and its tablet dosage form. The methods have been statistically evaluated and were found to be precise and accurate.

A Simple Colorimetric Method for the Determination of Raloxifene Hydrochloride in Pharmaceuticals Using Modified Romini’s Reagent

“…A few UV methods with UV detection have been previously reported for the determination of raloxifene hydrochloride in pharmaceuticals [4][5][6][7]. Other techniques reported for the assay of raloxifene in pharmaceuticals include HPLC [8][9][10][11][12][13], Rayleigh scattering method [14], LC-MS/MS [15], and capillary electrophoresis [16].…”

Eco‐friendly synthesis of gelatin‐capped bimetallic Au–Ag nanoparticles for chemiluminescence detection of anticancer raloxifene hydrochloride

“…Additionally, after the menopause, RLX can lower the chance of developing breast cancer . Owing to the importance of RLX in medicine, several analytical methods have been reported for its determination, including chromatographic and other spectroscopic methods, such as high performance liquid chromatography (HPLC) , liquid chromatography coupled with mass spectrometry (LC‐MS) , thin layer chromatography (TLC) , spectrophotometry and potentiometry .…”

Simple Estimation of Bosentan in Tablet Formulation by RP-HPLC

“…Chemically it contain 4-tertbutyl-N-[6-(2-hydroxyethoxy)-5-(2-ethoxyphenoxy)-2-(pyrimidin-2-yl) pyrimidin-4-yl] benzene-1-sulfonamide. Limited method has been reported only for spectroscopy and LC-MS-MS (Liquid Chromatography with Tandem Mass Spectrometry) [4][5][6][7][8][9]. As per our knowledge, no other method is available which is based on RP-HPLC (Reverse Phase-high Performance Liquid Chromatography) estimation.…”