Spectrophotometric determination of primary aromatic amines with 9-chloroacridine

Stewart, James T.; Shaw, Terry D.; Ray, Anthony B.

doi:10.1021/ac60271a044

Cited by 27 publications

(6 citation statements)

References 17 publications

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“…The colour produced from the reaction of hydrolyzed paracetamol with 9-CA suggested that a free amino function in the molecule is necessary for the reaction. This finding is in agreement with the reaction of primary aromatic amines and/or aromatic hydroxylamine's with the acridine (Gammans et al, 1974;Stewart and Lotti, 1970;Shaw et al, 1969;Ray et al, 1969) to form highly coloured solutions. However, the reaction mechanism has been explained in Scheme (1).…”

Section: Nature Of the Coloured Product And Stability Constantsupporting

confidence: 82%

Colorimetric Determination of Paracetamol Using 9-Chloroacridine Reagent: Application to Pharmaceutical Formulations

Awad

2020

Pak. j. sci. ind. res. Ser. A: phys. sci.

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This paper aims to develop a simple, sensitive and accurate spectrophotometric method for quantitative determination of paracetamol in aqueous medium. The method is based on the reaction between the hydrolyzed paracetamol and 9-chloroacridine reagent (9-CA). The spectra of the product show maximum absorption at 436 nm. Beer's law is obeyed in the concentration range of 0.25-11 µg/mL with molar absorptivity value 5.3x103 L/mol/cm. The average recovery percentage (Rec%) is 99.27% and relative standard deviation (RSD) is :: 2.82%. In addition, the stability constant has been determined and the reaction mechanism is proposed. The method has been applied successfully for the assay of paracetamol in pharmaceutical formulations. It is found that the method does not require extraction process and it agree well with British pharmacopeia.

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Section: Nature Of the Coloured Product And Stability Constantsupporting

confidence: 82%

Colorimetric Determination of Paracetamol Using 9-Chloroacridine Reagent: Application to Pharmaceutical Formulations

Awad

2020

Pak. j. sci. ind. res. Ser. A: phys. sci.

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“…The absorption curve in the visible spectrum for an analytical solution of N-phenylhydroxylamine shows an absorption maximum at 450 nm. Preliminary data have revealed that the reaction yields a nucleophilic addition product similar to the one reported for primary aromatic amines (12). Further work on the identification of the compound formed between arylhydroxylamines and 9-chloroacridine is under way in our laboratory.…”

Section: Methodssupporting

confidence: 53%

Determination of lead in paint with fast neutrons from a californium-252 source

Lutz¹

1974

Anal. Chem.

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We should not assign great significance a priori to the fact that our sensitivities are between others' values for £0 = 25 MeV and E0 = 30 MeV. Our distance sample-converter is greater (15 cm), and our electron beam intensity double (~210 µ ) theirs. However, these features result in opposite effects. Moreover, the general agreement of sensitivity ratios is quite important, because it implies activation trends for our system, parallel with those of thintarget, low-Eo facilities, for the whole range of giant resonance energies (k = 10 to 30 MeV). That is, it suggests reasonably similar bremsstrahlung spectrum shapeswithin said range-for the ORELA and conventional facilities (2, 4, 6), as we had expected from Figure 1.Table II shows, finally, that our sensitivities agree best with Lutz's results. The latter were obtained from a comprehensive table (2,4) which lists calculated sensitivities for 76 photon reactions on 59 elements for electron beam energies £0 = 25, 30, and 35 MeV. With reasonable approximation, the average ratios of Table II can be used to estimate sensitivities for our PAA system, from Lutz's table, for elements and reactions not included in our work. ACKNOWLEDGMENTWe thank J. A. Harvey and . A. Todd for their continuous interest in our work, and ORELA's operators for smooth scheduling and conduction of our bombardments.

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“…Previous reports from this laboratory showed the reaction to be applicable to colorimetric determinations of sulfonamides and local anesthetics as well as most primary aromatic amines (5)(6)(7). It was observed that the formation of these derivatives resulted in a quenching of the fluorescence of the 9-chloroacridine reagent solution.…”

Section: Resultsmentioning

confidence: 96%

Determination of Sulfonamides and Local Anesthetics with 9-Chloroacridine by Quenching Fluorometry

Stewart

Wilkin

1972

Journal of Pharmaceutical Sciences

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Spectrophotometric determination of primary aromatic amines with 9-chloroacridine

Cited by 27 publications

References 17 publications

Colorimetric Determination of Paracetamol Using 9-Chloroacridine Reagent: Application to Pharmaceutical Formulations

Colorimetric Determination of Paracetamol Using 9-Chloroacridine Reagent: Application to Pharmaceutical Formulations

Determination of lead in paint with fast neutrons from a californium-252 source

Determination of Sulfonamides and Local Anesthetics with 9-Chloroacridine by Quenching Fluorometry

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