Spectrophotometric determination of oxiconazole in topical lotion using methyl orange

Milano, Julie; Cardoso, Simone Gonçalves

doi:10.1016/j.jpba.2003.09.003

Cited by 13 publications

(4 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Extractive spectrophotometric procedures are popular for their sensitivity in the assay of drugs and hence, ion-pair extractive spectrophotometry has received a considerable attention for the quantitative determination of many pharmaceutical compounds. [15][16][17][18] TRH reacts with BTB and with BCP in acidic buffer to give chloroform soluble ion-association complexes ( Fig. 2), which exhibit absorption maxima at 423 and at 408 nm for BTB and BCP, respectively (Figs.…”

Section: Resultsmentioning

confidence: 99%

Sensitive Extractive Spectrophotometric Methods for the Determination of Trazodone Hydrochloride in Pharmaceutical Formulations

Kumar

Hadagali

Shaikh

et al. 2006

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

Two simple, rapid and sensitive extractive spectrophotometric methods have been developed for the assay of trazodone hydrochloride (TRH) in pure and pharmaceutical formulations. These methods are based on the formation of chloroform soluble ion-association complexes of TRH with bromothymol blue (BTB) and with bromocresol purple (BCP) in KCl-HCl buffer of pH 2.0 (for BTB) and in NaOAc-AcOH buffer of pH of 3.6 (for BCP) with absorption maximum at 423 nm and at 408 nm for BTB and BCP, respectively. Reaction conditions were optimized to obtain the maximum color intensity. The absorbance was found to increase linearly with increase in concentration of TRH, which was corroborated by the calculated correlation coefficient values (0.9996, 0.9945). The systems obeyed Beer's law in the range of 0.2-14.5 and 0.2-14.1 microg/ml for BTB and BCP, respectively. Various analytical parameters have been evaluated and the results have been validated by statistical data. No interference was observed from common excipients present in pharmaceutical formulations. The proposed methods are simple, accurate and suitable for quality control applications.

show abstract

Section: Resultsmentioning

confidence: 99%

Sensitive Extractive Spectrophotometric Methods for the Determination of Trazodone Hydrochloride in Pharmaceutical Formulations

Kumar

Hadagali

Shaikh

et al. 2006

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

show abstract

“…RESULT AND DISCUSSION: Spectrophotometric procedures are popular for their sensitivity in the assay of drugs and hence, ion-pair extractive spectrophotometry has received a considerable attention for the quantitative determination of many pharmaceutical compounds [15][16][17][18] . TRH reacts with (BPB) and with (CPR) in acidic buffer to give chloroform soluble ion-association complexes, which exhibit absorption maxima at 420 and at 410 nm for (BPB) and (CPR), respectively.…”

Section: Reagents and Chemicalsmentioning

confidence: 99%

Untitled

2011

IJPSR

View full text Add to dashboard Cite

Spectrophotometric methods have been developed for the assay of trazodone hydrochloride (TRH) in pure and pharmaceutical formulations. These method based on the formation of chloroform soluble ion-association complexes of TRH with bromphenol blue (BPB) and with chlorophenol red (CPR) in buffer of pH 2.0 (for BPB) and buffer of pH of 4 (for CPR) with absorption maximum at 420 nm and at 410 nm for BPB and CPR, respectively. Reaction conditions were optimized to obtain the maximum color intensity. The absorbance was found to increase linearly with increase in concentration of TRH, which was corroborated by the calculated correlation coefficient values (0.9996, 0.9945). The systems obeyed Beer's law in the range of 0.2-14.5 and 0.2-14.1m g/ml for (BPB) and (CPR), respectively. Various analytical parameters have been evaluated and the results have been validated by statistical data. No interference was observed from common excipients present in pharmaceutical formulations. The proposed methods are simple, accurate and suitable for quality control applications. INTRODUCTION: Trazodone hydrochloride, 2-{3-[4-(3chlorophenyl)-1-piperazinyl]propyl}-1, 2, 4-triazolo [4, 3-a]pyridin-3-(2H)-onemonohydrochloride, is a antidepressant. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders.

show abstract

“…This technique depends on the reaction of a drug that has a basic cationic nitrogen and an anionic dye at a suitable pH, where a highly coloured ion‐pair complex is formed. Also, methyl orange (MO) has been widely used as ion‐pairing reagent for quantitative analysis of many drugs in pharmaceutical formulations 29, 31–35. However, no report dealing with the extractive spectrophotometric determination of BUPH in drug forms has appeared so far.…”

Section: Introductionmentioning

confidence: 99%

“…Extractive spectrophotometric procedures are popular for their sensitivity in the assay of some drugs;26–30 therefore, ion‐pair extractive spectrophotometry has received considerable attention for the quantitative determination of many pharmaceutical compounds. This technique depends on the reaction of a drug that has a basic cationic nitrogen and an anionic dye at a suitable pH, where a highly coloured ion‐pair complex is formed.…”

Section: Introductionmentioning

confidence: 99%

Application of ion‐pair complexation reaction for the spectrophotometric determination of bupropion hydrochloride in pharmaceuticals

Basavaiah

Abdulrahman

2011

Drug Testing and Analysis

View full text Add to dashboard Cite

This is the first report on the use of visible spectrophotometry for the determination of bupropion hydrochloride (BUPH), a second-generation antidepressant, in pharmaceuticals. Two sensitive, selective, and cost-effective spectrophotometric methods are described. The first method (method A) is based on the formation of yellow-coloured ion-pair complex between the BUPH and methyl orange (MO) at pH 3.80 ± 0.10 which was extracted into dichloromethane and the absorbance measured at 425 nm. The second method (method B) is based on the breaking of the yellow BUPH-MO ion-pair complex in acid medium followed by the measurement of the red-pink colour at 520 nm. Beer's Law is obeyed over the concentration ranges of 1.00-12.0 and 0.48-7.20 µg ml(-1) BUPH for method A and method B, respectively. The molar absorptivities are calculated to be 2.18 × 10(4) and 3.79 × 10(4) l mol(-1) cm(-1) for method A and method B, respectively, and the corresponding Sandell sensitivity values are 0.0127 and 0.0073 µg cm(-2) . The limits of detection and quantification have also been reported. The proposed methods were applied successfully to the determination of BUPH in pure drug and commercial tablets. The accuracy and reliability of the proposed methods were further ascertained by recovery studies via standard addition technique.

show abstract

Spectrophotometric determination of oxiconazole in topical lotion using methyl orange

Cited by 13 publications

References 12 publications

Sensitive Extractive Spectrophotometric Methods for the Determination of Trazodone Hydrochloride in Pharmaceutical Formulations

Sensitive Extractive Spectrophotometric Methods for the Determination of Trazodone Hydrochloride in Pharmaceutical Formulations

Untitled

Application of ion‐pair complexation reaction for the spectrophotometric determination of bupropion hydrochloride in pharmaceuticals

Contact Info

Product

Resources

About