Spectrophotometric determination of Naproxen as ion-pair with bromophenol blue in bulk, pharmaceutical preparation and human serum samples

Keyhanian, Fereshteh; Alizadeh, Nina; Shojaie, Abdollah Fallah

doi:10.5267/j.ccl.2013.10.006

Cited by 15 publications

(7 citation statements)

References 17 publications

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“…The optimal reaction time was found to be 5 min at 30 o C after vortex mixing of the drug/reagent mixture for 10 s. The optimal analytical wavelength was found to be 470 nm (Idowu et al, 2009). Naproxen was determined by formation of ion-pair complex with bromophenol blue,the colored product was measured at 432 nm (Keyhanian et al,2014), another ion-pair procedure based on reaction between Naproxen with two sulfophthalein acid dyes, namely bromocresol green and bromothymol blue (Alizadeh and Keyhanian, 2015).…”

Section: Naproxen Structurementioning

confidence: 99%

A Creative Indirect Spectrophotometric Determination of Naproxen

Mahmood¹,

Al-Sarraj²

2019

RJS

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A New, sensitive spectrophotometric method for determination of Naproxen (Nap) has been proposed. The method is based on a modification of Naproxen into a hydroxy analog (mNap). The modified compound is coupled with the diazotized p-aminobenzoic acid (PABA) in alkaline medium, the resulting orange azo dye exhibit a maximum absorption at 500 nm. Beer's law is obeyed over the concentration range from 10 to 650 µg/20 ml, (i.e. 0.5-32.5 µg/ ml) with a good sensitivity (molar absorptivity 2.14x10 4 l.mol -1 .cm -1 ), good precision (RSD% better than ±1.93%) and high accuracy (relative error % better than 0.43%), Sandell's sensitivity index is 0.0107µg.cm -2 and the limit of detection (LOD) is 0.024 µg/ml and the limit of quantitation (LOQ) is 0.082 µg/ml. The method has been applied successfully for determination of Naproxen in dosage forms after extraction of the active ingredient.

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Section: Naproxen Structurementioning

confidence: 99%

A Creative Indirect Spectrophotometric Determination of Naproxen

Mahmood¹,

Al-Sarraj²

2019

RJS

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“…The influence of pH on the electrode response was checked by recording the electrode potential readings for NAP solutions containing 10 À4 to 10 À2 mol L À1 at different pH values (pH [6][7][8][9][10][11][12]. The electrode responses were pH independent in the range from 7-11.…”

Section: Sensor Performancementioning

confidence: 99%

“…They include chromatographic methods HPLC [4], TLC [5], gas chromatography-mass spectrometry [6], capillary electrophoresis [7], spectrophotometry [8,9], spectrofluorymetry [10], and non-aqueous potentiometric titration [11]. They include chromatographic methods HPLC [4], TLC [5], gas chromatography-mass spectrometry [6], capillary electrophoresis [7], spectrophotometry [8,9], spectrofluorymetry [10], and non-aqueous potentiometric titration [11].…”

Section: Introductionmentioning

confidence: 99%

Novel Calixarene/Carbon Nanotubes Based Screen Printed Sensors for Flow Injection Potentiometric Determination of Naproxen

et al. 2018

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Novel sensitive disposable sensors have been introduced for potentiometric determination of naproxen (NAP) based on single‐walled carbon nanotubes‐polyvinyl chloride (SWNTs‐PVC) composite incorporated of calix[4]arene as host‐guest molecular recognition element. The electrode matrix composition was optimized on the basis of the nature and content of the sensing element, cationic sites, plasticizer and nanomaterial. Remarkable selectivity and sensitivity towards NAP was achieved in the concentration range from 10−8 to 10−2 mol L−1 with anionic Nernstian compliance −61.0±0.0 mV decade−1. Modification with calixarene and carbon nanotubes improved the sensors performance through formation of NAP‐calixarene inclusion complex and promotion of the electron‐transfer processes which enhance the potential stability, response time, and shelf lifetime of the sensor. The proposed sensors were successfully applied for the potentiometric assay of NAP in dosage formulation and biological fluids under batch and flow injection analysis (FIA) conditions with average recoveries agreeable with the reported official methods.

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“…Like other NSAIDs, naproxen is capable of producing disturbances in the gastrointestinal tract; it is also associated with the smallest overall cardiovascular risks. Naproxen is rapidly and completely absorbed after oral administration, and it is the predominant species in serum, with a therapeutic range of 30–90 μg/mL .…”

Section: Introductionmentioning

confidence: 99%

Application of carbon nanotubes modified with a Keggin polyoxometalate as a new sorbent for the hollow‐fiber micro‐solid‐phase extraction of trace naproxen in hair samples with fluorescence spectrophotometry using factorial experimental design

Naddaf

Ebrahimi

Es’haghi

et al. 2015

J of Separation Science

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A sensitive technique to determinate naproxen in hair samples was developed using hollow-fiber micro-solid-phase combined with fluorescence spectrophotometry. The incorporation of multi-walled carbon nanotubes modified with a Keggin polyoxometalate into a silica matrix prepared by the sol-gel method was reported. In this research, the Keggin carbon nanotubes /silica composite was used in the pores and lumen of a hollow fiber as the hollow-fiber micro-solid-phase extraction device. The device was used for the microextraction of the analyte from hair and water samples under the optimized conditions. An orthogonal array experimental design with an OA24 (4(6) ) matrix was employed to optimize the conditions. The effect of six factors influencing the extraction efficiency was investigated: pH, salt, volume of donor and desorption phase, extraction and desorption time. The effect of each factor was estimated using individual contributions as response functions in the screening process. Analysis of variance was employed for estimating the main significant factors and their contributions in the extraction. Calibration curve plot displayed linearity over a range of 0.2-10 ng/mL with detection limits of 0.072 and 0.08 ng/mL for hair and aqueous samples, respectively. The relative recoveries in the hair and aqueous matrices ranged from 103-95%. The relative standard deviation for fiber-to-fiber repeatability was 3.9%.

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Spectrophotometric determination of Naproxen as ion-pair with bromophenol blue in bulk, pharmaceutical preparation and human serum samples

Cited by 15 publications

References 17 publications

A Creative Indirect Spectrophotometric Determination of Naproxen

A Creative Indirect Spectrophotometric Determination of Naproxen

Novel Calixarene/Carbon Nanotubes Based Screen Printed Sensors for Flow Injection Potentiometric Determination of Naproxen

Application of carbon nanotubes modified with a Keggin polyoxometalate as a new sorbent for the hollow‐fiber micro‐solid‐phase extraction of trace naproxen in hair samples with fluorescence spectrophotometry using factorial experimental design

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