Spectrophotometric determination of maneb by ternary complex formation with PAR and CTAB

Kapoor, Jyoti; Kumar, Ashok; Gupta, Usha; Rao, A. L. J.

doi:10.1016/0039-9140(94)00179-0

Cited by 7 publications

(5 citation statements)

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“…Maneb is a manganese-containing ethylenebis-dithiocarbamate fungicide (EBDCs) (Kanchi et al, 2014). Maneb is widely used as a pesticide on fruit and nut crops, vegetable crops, field and forage crops, grapes, field crop seeds, and other varied grains and legumes (Kapoor et al, 1994; EPA, 2005). Approximately 9 million pounds of the manganese-containing fungicides mancozeb and maneb were applied annually in the U.S. (EPA, 2011), and a significant amount of chemical is released annually into the environment.…”

Section: Pesticidesmentioning

confidence: 99%

Elucidating Conserved Transcriptional Networks Underlying Pesticide Exposure and Parkinson's Disease: A Focus on Chemicals of Epidemiological Relevance

et al. 2019

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While a number of genetic mutations are associated with Parkinson's disease (PD), it is also widely acknowledged that the environment plays a significant role in the etiology of neurodegenerative diseases. Epidemiological evidence suggests that occupational exposure to pesticides (e.g., dieldrin, paraquat, rotenone, maneb, and ziram) is associated with a higher risk of developing PD in susceptible populations. Within dopaminergic neurons, environmental chemicals can have an array of adverse effects resulting in cell death, such as aberrant redox cycling and oxidative damage, mitochondrial dysfunction, unfolded protein response, ubiquitin-proteome system dysfunction, neuroinflammation, and metabolic disruption. More recently, our understanding of how pesticides affect cells of the central nervous system has been strengthened by computational biology. New insight has been gained about transcriptional and proteomic networks, and the metabolic pathways perturbed by pesticides. These networks and cell signaling pathways constitute potential therapeutic targets for intervention to slow or mitigate neurodegenerative diseases. Here we review the epidemiological evidence that supports a role for specific pesticides in the etiology of PD and identify molecular profiles amongst these pesticides that may contribute to the disease. Using the Comparative Toxicogenomics Database, these transcripts were compared to those regulated by the PD-associated neurotoxicant MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). While many transcripts are already established as those related to PD (alpha-synuclein, caspases, leucine rich repeat kinase 2, and parkin2), lesser studied targets have emerged as “pesticide/PD-associated transcripts” [e.g., phosphatidylinositol glycan anchor biosynthesis class C (Pigc), allograft inflammatory factor 1 (Aif1), TIMP metallopeptidase inhibitor 3, and DNA damage inducible transcript 4]. We also compared pesticide-regulated genes to a recent meta-analysis of genome-wide association studies in PD which revealed new genetic mutant alleles; the pesticides under review regulated the expression of many of these genes (e.g., ELOVL fatty acid elongase 7, ATPase H+ transporting V0 subunit a1, and bridging integrator 3). The significance is that these proteins may contribute to pesticide-related increases in PD risk. This review collates information on transcriptome responses to PD-associated pesticides to develop a mechanistic framework for quantifying PD risk with exposures.

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Section: Pesticidesmentioning

confidence: 99%

Elucidating Conserved Transcriptional Networks Underlying Pesticide Exposure and Parkinson's Disease: A Focus on Chemicals of Epidemiological Relevance

et al. 2019

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“…25 Alternatively, the metal present in the fungicide can be released by ligand exchange. 6,7 The elution of adsorbed chelates from the C 60 column was thus investigated using different solutions, namely: (i) organic solvents (nhexane, IBMK); (ii) HNO 3 at different concentrations; and (iii) ethylenediaminetetraacetic acid sodium salt (EDTA) at different concentrations. The results obtained in these experiments were satisfactory for the three fungicides.…”

Section: Influence Of Sample Ph and Eluentmentioning

confidence: 99%

“…Therefore, the proposed method affords group speciation in grain samples, and also, probably, in vegetables and fruits, as they act as surface deposits and hence contain residues of undecomposed fungicides. 6…”

Section: Speciation and Determination Of Dithiocarbamates In Grain Sa...mentioning

confidence: 99%

“…However, most of these methods are non-specific, as all dithiocarbamates (e.g., ziram, zineb, ferbam, maneb, nabam) yield CS 2 . Diethyldithiocarbamates (DDCs) have been determined by spectrophotometry at the mg ml 21 level, [6][7][8] and by using bioenzymic sensors with amperometric detection at the ng ml 21 level; 9,10 adsorptive stripping voltammetry 11 and flame atomic absorption spectrometry (FAAS) 12 have also been used for this purpose. In the last work, DDCs were continuously extracted into isobutyl methyl ketone (IBMK) following complexation with excess copper(II), the metal being determined by FAAS.…”

Section: Introductionmentioning

confidence: 99%

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Group speciation of metal dithiocarbamates by sorption on C60 fullerene

Baena

Gallego

Valcárcel

2000

Analyst

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A simple flow injection system for the on-line preconcentration of metal dithiocarbamates (fungicides) by sorption on a C 60 fullerene column was developed. Neither the acid hydrolysis needed by the conventional method to release CS 2 nor derivatization is required as the fungicides are directly retained on the sorbent column and subsequently eluted from it with dilute HNO 3 . The eluted fraction is directly fed into a flame atomic absorption spectrometer. Group speciation can be done according to the metals present in the dithiocarbamate (viz., dithiocarbamates of Zn 2+ , Mn 2+ , or Fe 3+ ) but no within-group discrimination is possible (ziram, zineb and propineb provide a global response). The analytical figures of merit of the proposed method are as follows: limits of detection (3s) from 1 to 5 ng ml 21 ; precision (RSD) ca. 2.5%; and preconcentration factor 45 (using 10 ml of sample). No interference from metals such as Zn, Mn or Fe, as inorganic salts, was observed. The method was applied to the resolution of synthetic mixtures as well as to the speciation/determination of ziram, maneb and ferbam in spiked grain samples, all with acceptable recoveries. Experimental ApparatusA Perkin-Elmer 380 atomic absorption spectrometer equipped with a bead impact system in the burner chamber and with an

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“…In agriculture it is often used as a fungicide to treat fruits, vegetables, wheat, and shelled crops such as walnut, hazelnut, and pistachio (8) and is quite common in Turkey (9).…”

mentioning

confidence: 99%

Acute toxicity of maneb in the tadpoles of common and green toad / Akutna toksičnost maneba u punoglavaca smeđe i zelene krastače

Gürkan

Hayretdağ

2015

Archives of Industrial Hygiene and Toxicology

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Pesticides used in agriculture can have hazardous effects on aquatic organisms, and amphibians are even more threatened than other aquatic vertebrates. Maneb is widely used to control fungal diseases on crops, fruits, and vegetables. The aim of this study was to investigate the acute toxic effects of maneb on the common (Bufo bufo) and green toad (Pseudepidalea viridis) tadpoles. Tadpoles at the development stage 21 were exposed to maneb (0-5 mg L -1 ) for 120 h. Maneb LC 50 values at hour 120 were 1.966 mg L -1 for B. bufo and 0.332 mg L -1 for P. viridis. To the best of our knowledge, these are the first published LC 50 findings for the two species. Visceral oedema and tail deformations were observed in both species. We also observed liver necrosis, pronephric tubule deformations, somite deteriorations, and visceral oedema at maneb concentrations ≥0.1 mg L -1 for B. bufo and ≥0.05 mg L -1 for P. viridis. Our results show that B. bufo tadpoles have a much higher resilience to maneb than P. viridis tadpoles. This resilience seems to be related to the larger size of the B. bufo tadpoles and their ability to metamorphose faster in adverse conditions. Future research should look into the mechanisms of toxic action of maneb in anurans.

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Spectrophotometric determination of maneb by ternary complex formation with PAR and CTAB

Cited by 7 publications

References 10 publications

Elucidating Conserved Transcriptional Networks Underlying Pesticide Exposure and Parkinson's Disease: A Focus on Chemicals of Epidemiological Relevance

Elucidating Conserved Transcriptional Networks Underlying Pesticide Exposure and Parkinson's Disease: A Focus on Chemicals of Epidemiological Relevance

Group speciation of metal dithiocarbamates by sorption on C60 fullerene

Acute toxicity of maneb in the tadpoles of common and green toad / Akutna toksičnost maneba u punoglavaca smeđe i zelene krastače

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