Spectrophotometric determination of lansoprazole in pharmaceuticals using bromate-bromide mixture based on redox and complexation reactions

Basavaiah, K.; Ramakrishna, V.; Kumar, U. R. Anil; Somashekar, B. C.

doi:10.1590/s0100-46702007000100008

Cited by 13 publications

(8 citation statements)

References 7 publications

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“…According to the data presented by Gupta et al (4), a dramatic increase in the degradation rate of LPZ was observed as the pH dropped only one pH unit from 6 to 5. LPZ has been quantitatively determined in formulations using different analytical methods including spectrophotometry, highperformance liquid chromatography (HPLC), and thinlayer chromatography (5)(6)(7)(8)(9)(10)(11)(12)(13)(14).…”

Section: Ansoprazole (Lpz Shown Inmentioning

confidence: 99%

Assessment of the Pharmacopeial Analytical Methodologies in the Dissolution Test of Enteric-Coated Lansoprazole Preparations

Hammad¹,

Hamdan²,

El-Sabawi³

2016

Dissolution Technol.

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The performance of the analytical methodologies recommended by the United States Pharmacopoeia (USP) monograph (1) for dissolution testing of lansoprazole (LPZ) enteric-coated solid dosage forms (capsules/tablets) was critically evaluated. While USP adopts an essentially nonselective UV method, the British Pharmacopoeia (2) recommends a highperformance liquid chromatography (HPLC) method capable of separating the drug from its acid degradation products. For an acid-labile drug such as LPZ, one might think that the nonselective UV method might over-or underestimate the percentage released because the degradation product might have UV absorptivity different from that of the parent drug. We subjected six commercial products in addition to the reference product (G) to analysis according to the USP assay and dissolution recommendations. Products were also subjected to dissolution tests whereby a selective HPLC method was employed for quantifying the percentage release. All products passed USP assay tests. For dissolution, the UV method adopted by USP was more reliable because it indicated the actual percentage released compared with the selective HPLC method, which reflected only the percentage of released LPZ that remained intact (undegraded). Only one product (E) failed to satisfy the USP requirements for dissolution.

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Section: Ansoprazole (Lpz Shown Inmentioning

confidence: 99%

Assessment of the Pharmacopeial Analytical Methodologies in the Dissolution Test of Enteric-Coated Lansoprazole Preparations

Hammad¹,

Hamdan²,

El-Sabawi³

2016

Dissolution Technol.

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“…A number of colour formation reactions utilizing different reagents have been employed for the visible spectrophotometric determination of LAN in pharmaceuticals [4,12,40,[44][45][46][47][48][49][50][51][52][53][54][55][56]. The reported methods are based on complexation and oxidative coupling [44], formation of a charge-transfer complex [4,45], redox followed by complexation or colour bleaching [46][47][48][49], bromination [50], ion-pair complexation reaction [51][52][53][54][55] and coupling with diazotized p-nitroaniline [56]. However, most of the reported visible spectrophotometric methods suffer from one or more disadvantages, such as poor sensitivity [4,44,45], a narrow range of determination [47][48][49][50], use of a heating step [44,48], and use of an extraction step [52][53][54][55], as shown in Table 1.…”

Section: Introductionmentioning

confidence: 99%

Use of picric acid and iodine as electron acceptors for spectrophotometric determination of lansoprazole through a charge-transfer complexation reaction

Abdulrahman

Devi

Basavaiah

et al. 2016

Journal of Taibah University for Science

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“…Literature survey revealed that the only visible spectrophotometric method 3 reported is based on the formation of a blue chromogen measurable at 810 nm when LPZ was reacted with iron(III) chloride and ferricyanide in HCl medium. Few more methods such as HPLC 4-6 , HPTLC 7 , LC-MS-MS 8,9, Tirimetric 10-12, UV spectrophotometry 13,14 and visible spectrophotometry 15 , relatively little attention was paid to the development of visible spectrophotometric methods for this drug.…”

Section: Introductionmentioning

confidence: 99%

Extractive Spectroscopic Determination of Lansoprazole in Pharmaceutical Dosage Form

Rizwana¹,

Prakash²,

Mohan³

2014

Chem Sci Trans

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Two simple and sensitive extractive spectrophotometric methods have been described for the assay of Lansoprazole (LPZ) either in pure form or in pharmaceutical formulations. The methods were based on the formation of ion-pair complex between LPZ and Metanil Yellow (MY) -Method-A and methyl orange (MO)-Method-B, at pH 2.5 has been described. The formed complex were extracted quantitatively into chloroform and measured at 440 nm and 450 nm with MY and MO respectively. Beer's law was obeyed in the concentration range of 20-70 µg mL -1 and 6-16 µg mL -1 with molar absorptivity of 1.329 x 10 -8 and 1.822 x 10 -8 L mol -1 cm -1 with MY and MO respectively. Statistical comparison of the results of the proposed method with those of the reference method shows excellent agreement and indicates no significant difference in accuracy and precision. The limits of detection and quantification have been determined for two methods. Both the methods have been validated as per the guidelines of ICH. The methods have been applied to the determination of drug in commercial capsules and results of analysis were validated statistically through recovery studies

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Spectrophotometric determination of lansoprazole in pharmaceuticals using bromate-bromide mixture based on redox and complexation reactions

Cited by 13 publications

References 7 publications

Assessment of the Pharmacopeial Analytical Methodologies in the Dissolution Test of Enteric-Coated Lansoprazole Preparations

Assessment of the Pharmacopeial Analytical Methodologies in the Dissolution Test of Enteric-Coated Lansoprazole Preparations

Use of picric acid and iodine as electron acceptors for spectrophotometric determination of lansoprazole through a charge-transfer complexation reaction

Extractive Spectroscopic Determination of Lansoprazole in Pharmaceutical Dosage Form

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