Spectrophotometric determination of ciprofloxacin, enrofloxacin and pefloxacin through charge transfer complex formation

Mostafa, Samia M.; El-Sadek, Mohamed; Alla, Esmail Awad

doi:10.1016/s0731-7085(01)00524-6

Cited by 147 publications

(64 citation statements)

References 6 publications

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“…Various spectrophotometric methods were described for determination of CIP, ENR and PEF [12] , NOR [13] and LEV [14] by charge-transfer complex formation with chloranilic acid, tetracyanoquinodimethane and tetracyanoethylene. In addition, several techniques have been reported for their determination such as spectrophotometry [15,16] , fluorimetry [17][18][19] , polarography [20] , voltametry [21] and capillary electrophoresis [22] .…”

Section: Introductionmentioning

confidence: 99%

Spectrofluorimetric Determination of Certain Fluoroquinolones Through Charge Transfer Complex Formation

Salem¹,

Fada²,

Khater³

2007

American J. of Pharmacology and Toxicology

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A highly sensitive spectrofluorimetric method was developed for the first time, for the analysis of ten fluoroquinolones (FQs) antibacterials, namely amifloxacin (AMI), ciprofloxacin (CIP), difloxacin (DIF), enoxacin (ENO), enrofloxacin (ENR), lomefloxacin (LOM), levofloxacin (LEV), norfloxacin (NOR), ofloxacin (OFL) and pefloxacin (PEF) in their pharmaceutical dosage forms or in biological fluids through charge transfer (CT) complex formation with bromanil (BRO). The BRO was found to react with these drugs to produce stable complexes and the fluorescence intensity of the complexes was greatly enhanced. The formation of such complexes was also confirmed by ultravioletvisible measurements. The different experimental parameters that affect the fluorescence intensity were carefully studied. At the optimum reaction conditions, the drug-BRO complexes showed excitation maxima ranging from 275 to 290 nm and emission maxima ranging from 450 to 470 nm. Rectilinear calibration graphs were obtained in the concentration range 0.02 to 3.1 µg.mL -1 for the studied drugs. The method has been successfully applied to determine their pharmaceutical dosage forms with good precision and accuracy compared to official and reported methods as revealed by tand F-tests. They are also applied for the determination of studied drugs in human urine samples.

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Section: Introductionmentioning

confidence: 99%

Spectrofluorimetric Determination of Certain Fluoroquinolones Through Charge Transfer Complex Formation

Salem¹,

Fada²,

Khater³

2007

American J. of Pharmacology and Toxicology

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“…From Table I, it is clear that the proposed spectrophotometric method is highly selective compared to most existing methods (7,(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25). The most striking feature of the method is its extraordinary Brought to you by | MIT Libraries Authenticated Download Date | 5/11/18 1:39 AM sensitivity, which is comparable to that of the spectrofluorometric method.…”

Section: Application To Dosage Formsmentioning

confidence: 99%

“…A few visible spectrophotometric methods based on acid-base (15), redox (7,(16)(17)(18), oxidative coupling (19), complex formation (20)(21)(22)(23)(24) reactions have been earlier reported for the determination of PFM in dosage forms. The reported methods have their respective advantages and disadvantages as indicated in Table 1.…”

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confidence: 99%

Spectrophotometric determination of pefloxacin mesylate in pharmaceuticals

Basavaiah

Prameela²,

Somashekar³

2007

Acta Pharmaceutica

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Pefloxacin mesylate dihydrate (PFM) is a fluorinated quinolone structurally related to nalidixic acid. Chemically, PFM, is 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-peperazinyl)-4-oxo-3-quinolinecarboxylic acid, methane sulfonate dihydrate (Fig. 1). It is an antibacterial drug, which is highly effective against both Gram-negative and Gram-positive pathogens that are resistant to other antibacterials (1). The therapeutic importance of PFM has necessitated the development of analytical methods for its determination in dosage forms in compliance with good manufacturing standards. The drug is official in British and European Pharmacopoeias which describe a potentiometric non-aqueous titration procedure for its assay (2, 3). The drug has been determined in pharmaceutical formulations by a variety of analytical techniques such as UV-spectrophotometry (4, 5), A spectrophotometric method is described for assay of pefloxacin mesylate (PFM) in bulk drug and in tablets. The method is based on back extraction of the bromophenol blue dye at pH 5.2 from the dye-drug ion pair followed by measurement of the dye absorbance at 590 nm. The working conditions of the method were investigated and optimized. Beer's law plot showed a good correlation in the concentration range of 0.15-1.25 mg mL -1 . Sensitivity indices such as molar absorptivity, limits of detection and quantification are reported. Intra-day and inter-day precision, and accuracy of the methods were established according to the ICH guidelines, and the e r values were in the range of -1.7 to 1.8% with RSD values ranging from 1.0 to 1.1%. The method was successfully applied to the assay of PFM in tablet preparations with recoveries varying from 97.5 to 101.9%, with standard deviation in the range of 0.6 to 1.9. The results were statistically compared with those of the reference method by applying Student's t-test and F-test. Accuracy evaluated by means of the spike recovery method, range from 97.0 to 106.0%, with precision better than 3%.

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“…The HPTLC method has been developed for the determination and the purity control of CF in coated tablets [14,15]. Other different methods were reported such as spectrophotometry [16][17][18][19][20][21][22], fluorimetry [22][23][24], capillary electrophoresis [25][26][27][28][29][30][31][32] and immunoassay [33,34]. Both spectrophotometric [35][36][37][38] and chemiluminescent [39,40] detection were proposed as automatic spectroscopy procedures.…”

Section: Introductionmentioning

confidence: 99%

Preconcentration and Determination of Ciprofloxacin with Solid-phase Microextraction and Silica-coated Magnetic Nanoparticles Modified with Salicylic Acid by UV-Vis Spectrophotometry

Neshin¹,

Ebrahimi²

2018

Eurasian J Anal Chem

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In the present age, the pharmaceutical application continues to increase and this results in the environmental pollution. As a result, pharmaceutical control is a common technique in many labs. This project is on the improvement of the procedure to determine a small amount of ciprofloxacin (CF) in bio-environmental sample. Regarding the fact that each method requires preliminary measures to preconcentrate and prepare analyte prior to measurement and recognition. In recent study, preconcentration of samples containing CF (as antibiotic) based on solid-phase microextraction method using silica-coated magnetic nanoparticles modified with salicylic acid (SA) was proposed which acted as sorbent. In addition, UV-Vis spectrophotometry was carried out to determine the amount of CF. The wavelength of maximum absorption (λmax) for this drug was 275 nm. Also, the optimum conditions of various parameters such as pH of solution, amount of magnetic nanoparticles, time, the effect of stirring speed on the extraction and desorption, the rate of centrifugation, the volume of aqueous and organic-phases, temperature and salt effect were investigated. The dynamic range was obtained between 0.05-0.15 mg L -1 , LOD and RSD (%) were 0.002 mg L -1 and 1.878 respectively. Results showed using this procedure increased the concentration factor to 68.36. Relative recovery was achieved by spike method.

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Spectrophotometric determination of ciprofloxacin, enrofloxacin and pefloxacin through charge transfer complex formation

Cited by 147 publications

References 6 publications

Spectrofluorimetric Determination of Certain Fluoroquinolones Through Charge Transfer Complex Formation

Spectrofluorimetric Determination of Certain Fluoroquinolones Through Charge Transfer Complex Formation

Spectrophotometric determination of pefloxacin mesylate in pharmaceuticals

Preconcentration and Determination of Ciprofloxacin with Solid-phase Microextraction and Silica-coated Magnetic Nanoparticles Modified with Salicylic Acid by UV-Vis Spectrophotometry

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