2008
DOI: 10.1155/2008/954232
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Spectrophotometric Determination of Adefovir Dipivoxil in bulk and Pharmaceutical Formulation

Abstract: Two selective and sensitive spectrophotometric methods have been developed for the estimation of adefovir dipivoxil in bulk and pharmaceutical preparations. Adefovir dipivoxil was subjected to acid hydrolysis and the hydrolysed product used for the estimation. The methods are based on the reaction with 3-methyl-2-benzothiazolinone hydrazone in the presence of ferric chloride, to form a colored species with absorption maxima at 627 nm. The second method is based on the reaction of drug with 1,2 naphthaquinone -… Show more

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“…Several techniques have been explored for detection and quantification of Adefovir in pharmaceutical formulation and biological fluids such as spectrophotometry [5] , high performance liquid chromatography [6] , [7] , ion-pair liquid chromatography [8] , [9] , hydrophilic interaction liquid chromatography–tandem mass spectrometry [10] and liquid chromatography–tandem mass spectrometry [11] , [12] . Although spectrophotometry and chromatography are the most commonly employed techniques, but these involve many derivatization steps and extraction purification approaches prior to final analysis.…”
Section: Introductionmentioning
confidence: 99%
“…Several techniques have been explored for detection and quantification of Adefovir in pharmaceutical formulation and biological fluids such as spectrophotometry [5] , high performance liquid chromatography [6] , [7] , ion-pair liquid chromatography [8] , [9] , hydrophilic interaction liquid chromatography–tandem mass spectrometry [10] and liquid chromatography–tandem mass spectrometry [11] , [12] . Although spectrophotometry and chromatography are the most commonly employed techniques, but these involve many derivatization steps and extraction purification approaches prior to final analysis.…”
Section: Introductionmentioning
confidence: 99%